The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Hodgkin's Lymphoma after Autologous Hematopoietic Stem Cell Transplantation for Angioimmunoblastic T-cell Lymphoma

자가조혈모세포 이식 후 발생한 호지킨림프종

  • Park, Su-Youn (Department of Internal Medicine, Konkuk University School of Medicine) ;
  • Yu, Hyung Min (Department of Internal Medicine, Konkuk University School of Medicine) ;
  • Kim, Jiwan (Department of Internal Medicine, Konkuk University School of Medicine) ;
  • An, Sang Hee (Department of Internal Medicine, Konkuk University School of Medicine) ;
  • Kim, Wook Youn (Department of Pathology, Konkuk University School of Medicine) ;
  • Hur, Mina (Department of Laboratory Medicine, Konkuk University School of Medicine) ;
  • Lee, Hong Gi (Department of Internal Medicine, Konkuk University School of Medicine)
  • 박수연 (건국대학교 의학전문대학원 내과학교실) ;
  • 유형민 (건국대학교 의학전문대학원 내과학교실) ;
  • 김지완 (건국대학교 의학전문대학원 내과학교실) ;
  • 안상희 (건국대학교 의학전문대학원 내과학교실) ;
  • 김욱연 (건국대학교 의학전문대학원 병리학교실) ;
  • 허미나 (건국대학교 의학전문대학원 진단검사의학교실) ;
  • 이홍기 (건국대학교 의학전문대학원 내과학교실)
  • Received : 2013.07.05
  • Accepted : 2013.10.02
  • Published : 2014.06.01
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Abstract

Post-transplantation lymphoproliferative disorder (PTLD) is a serious complication that can develop after either solid organ or hematopoietic stem cell transplantation (HSCT). The incidence of Hodgkin's lymphoma (HL) ranges from 0.5-1.0% of PTLD after HSCT without T-cell depletion. Here, we report a case of HL-PTLD that occurred after autologous peripheral blood stem cell transplantation for an angioimmunoblastic T-cell lymphoma (AITL). A 36-year-old patient developed fever and chills with multiple lymphadenopathies at day 673 after auto-HSCT for AITL. Three months after the transplant, the patient developed fever with elevated plasma Epstein-Barr virus (EBV)-PCR values. The excisional biopsy revealed HL at Ann Arbor stage IIIB. A total of 8 cycles of chemotherapy with ABVD please define were performed, and the patient has remained disease-free. To our knowledge, this is first case report of HL-PTLD after auto-PBSCT in Korea.

이식 후 림프증식 질환은 이식 환자에서 면역 억제로 인하여 나타나는 치명적 부작용으로서 보통 Epstein-Barr 바이러스(EBV) 감염에 따른 저항력 약화가 발생 원인으로 추정된다. 36세 남자가 혈관면역모세포 T세포림프종 치료를 위한 자가조혈모세포이식 후 673일째 오한, 발열을 주소로 내원하여 다발성 림프절 비대가 발견되었다. 조직검사 및 면역화학염색으로 Reed-Sternberg 세포와 EBV를 확인하였으며 호지킨림프종으로 진단되었다. 총 8주기의 ABVD 복합 항암화학요법을 시행하였으며 잔단 후 15개월이 경과한 현재 완전관해 상태를 유지하고 있다. 본 증례는 자가조혈모세포 이식 후 발생한 호지킨림프종으로 국내에서는 첫 보고 사례이다.

Keywords

References

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