Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)
- Volume 12 Issue 1
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- Pages.31-34
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- 2014
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- 1738-1320(pISSN)
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- 2508-6332(eISSN)
A Case of Acute Hepatic Failure due to Acetaminophen Overdose Treated with Molecular Adsorbents Recirculating System$^{(R)}$
Acetaminophen 중독에 의한 급성 간 부전 환자에서 Molecular Adsorbents Recirculating System$^{(R)}$ 을 이용한 치험 1례
- Yang, Byung Keun (Department of Emergency Medicine, Yonsei University College of Medicine) ;
-
You, Je Sung
(Department of Emergency Medicine, Yonsei University College of Medicine) ;
- Joo, Young Seon (Department of Emergency Medicine, Yonsei University College of Medicine) ;
- Chung, Sung Phil (Department of Emergency Medicine, Yonsei University College of Medicine) ;
- Lee, Hahn Schick (Department of Emergency Medicine, Yonsei University College of Medicine)
- 양병근 (연세대학교 의과대학 응급의학교실) ;
-
유제성
(연세대학교 의과대학 응급의학교실) ;
- 주영선 (연세대학교 의과대학 응급의학교실) ;
- 정성필 (연세대학교 의과대학 응급의학교실) ;
- 이한식 (연세대학교 의과대학 응급의학교실)
- Received : 2014.04.05
- Accepted : 2014.05.22
- Published : 2014.06.30
Abstract
We report on a patient who developed acute hepatic failure despite intravenous N-acetyl cysteine therapy who was treated with the Molecular Adsorbents Recirculating System (MARS). She presented 20 hours after the ingestion of 13 g of acetaminophen. The MARS is based on albumin dialysis principle which can be applied for patients with acute poisoning from drugs that have high protein-binding capacity because of its ability to selectively remove from circulation protein-bound toxins. The clinical toxicologist should be consider this technology when treating patients with hepatic failure following acetaminophen poisoning.