Journal of the Korean Society for Precision Engineering (한국정밀공학회지)

Korean Society for Precision Engineering (한국정밀공학회)
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Fabrication of Blended PCL/β-TCP Scaffolds by Mixture Ratio of β-TCP using Polymer Deposition System

폴리머 적층 시스템을 이용한 β-TCP 혼합 비율에 따른 PCL/β-TCP 인공지지체의 제작

  • Ha, Seong-Woo (Department of Mechanical Engineering, Andong National University) ;
  • Kim, Jong Young (Department of Mechanical Engineering, Andong National University)
  • Received : 2014.02.26
  • Accepted : 2014.06.23
  • Published : 2014.09.01
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Abstract

Abstract Scaffold used as a carrier of the cell has been actively conducted using plenty of technology in tissue engineering. ${\beta}$-tricalcium phosphate (${\beta}$-TCP) material has shown good biocompatibility and osteoconductive ability when it was implanted as a bone graft substitute in osseous defect in human and animal studies for bone regeneration. In this study, we fabricated the blended polycaprolactone (PCL) and ${\beta}$-TCP scaffold by the polymer deposition system (PDS). The PCL/${\beta}$-TCP scaffold was fabricated at a temperature of $110^{\circ}C$, pressure of 650 kPa, and scan velocity of 100 mm/sec. The Overall geometry and size of the scaffold were fixed circle type with a diameter of 10 mm and a height of 4 mm. PCL/${\beta}$-TCP scaffold was observed by scanning electron microscopy. Cell attachment and proliferation of the scaffold containing 30 wt% ${\beta}$-TCP was superior to those containing 10 wt% and 20 wt% ${\beta}$-TCP.

Keywords

References

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