Radiation Oncology Journal

  • 제32권2호
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  • Pages.57-62
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  • 2014
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  • 2234-1900(pISSN)
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  • 2234-3156(eISSN)
대한방사선종양학회 (The Korean Society for Radiation Oncology)
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The association of rectal equivalent dose in 2 Gy fractions (EQD2) to late rectal toxicity in locally advanced cervical cancer patients who were evaluated by rectosigmoidoscopy in Faculty of Medicine, Chiang Mai University

  • Tharavichtikul, Ekkasit (Division of Therapeutic Radiology and Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University) ;
  • Meungwong, Pooriwat (Lampang Cancer Hospital) ;
  • Chitapanarux, Taned (Department of Medicine, Faculty of Medicine, Chiang Mai University) ;
  • Chakrabandhu, Somvilai (Division of Therapeutic Radiology and Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University) ;
  • Klunklin, Pitchayaponne (Division of Therapeutic Radiology and Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University) ;
  • Onchan, Wimrak (Division of Therapeutic Radiology and Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University) ;
  • Wanwilairat, Somsak (Division of Therapeutic Radiology and Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University) ;
  • Traisathit, Patrinee (Biostatistics and Applied Statistics Laboratory, Department of Statistics, Faculty of Science, Chiang Mai University) ;
  • Galalae, Razvan (Faculty of Medicine, Christian-Albrechts University at Kiel) ;
  • Chitapanarux, Imjai (Division of Therapeutic Radiology and Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University)
  • 투고 : 2014.02.25
  • 심사 : 2014.05.22
  • 발행 : 2014.06.30
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초록

Purpose: To evaluate association between equivalent dose in 2 Gy (EQD2) to rectal point dose and gastrointestinal toxicity from whole pelvic radiotherapy (WPRT) and intracavitary brachytherapy (ICBT) in cervical cancer patients who were evaluated by rectosigmoidoscopy in Faculty of Medicine, Chiang Mai University. Materials and Methods: Retrospective study was designed for the patients with locally advanced cervical cancer, treated by radical radiotherapy from 2004 to 2009 and were evaluated by rectosigmoidoscopy. The cumulative doses of WPRT and ICBT to the maximally rectal point were calculated to the EQD2 and evaluated the association of toxicities. Results: Thirty-nine patients were evaluated for late rectal toxicity. The mean cumulative dose in term of EQD2 to rectum was 64.2 Gy. Grade 1 toxicities were the most common findings. According to endoscopic exam, the most common toxicities were congested mucosa (36 patients) and telangiectasia (32 patients). In evaluation between rectal dose in EQD2 and toxicities, no association of cumulative rectal dose to rectal toxicity, except the association of cumulative rectal dose in EQD2 >65 Gy to late effects of normal tissue (LENT-SOMA) scale ${\geq}$ grade 2 (p = 0.022; odds ratio, 5.312; 95% confidence interval, 1.269-22.244). Conclusion: The cumulative rectal dose in EQD2 >65 Gy have association with ${\geq}$ grade 2 LENT-SOMA scale.

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피인용 문헌

  1. Five-year results for image-guided brachytherapy (IGBT) for cervical carcinoma: a report from single institute of Thailand vol.16, pp.1, 2014, https://doi.org/10.1017/s1460396916000510
  2. Acute radiation toxicity during and after concurrent chemoradiotherapy in patients with localy advanced cervical cancer vol.10, pp.2, 2018, https://doi.org/10.5937/racter10-18049
  3. High dose-rate tandem and ovoid brachytherapy in cervical cancer: dosimetric predictors of adverse events vol.13, pp.1, 2014, https://doi.org/10.1186/s13014-018-1074-2