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Side Effects of Chemotherapy among Cancer Patients in a Malaysian General Hospital: Experiences, Perceptions and Informational Needs from Clinical Pharmacists

  • Published : 2014.07.15

Abstract

Background: This study aimed to assess the most common physical side effects experienced by local chemotherapy patients. Their perceptions of these side effects and informational needs from clinical pharmacists were also evaluated. Materials and Methods: This was a single-center, cross-sectional study. A face-to-face interview guided by a structured questionnaire with cancer patients admitted to receive repeated cycles of chemotherapy was conducted. Information collected included chemotherapy-related side effects after last chemotherapy experience, the most worrisome side effects, the side effects overlooked by healthcare professionals and the preferred method, amount and source of receiving related information. Results: Of 99 patients recruited, 90 participated in this survey (response rate: 90.9%). The majority were in the age range of 45-64 years (73.3%) and female (93.3%). Seventy-five (83.3%) and seventy-one (78.9%) experienced nausea and vomiting, respectively. Both symptoms were selected as two of the most worrisome side effects (16.7% vs. 33.3%). Other common and worrisome side effects were hair loss and loss of appetite. Symptoms caused by peripheral neuropathies were perceived as the major symptoms being overlooked (6.7%). Most patients demanded information about side effects (60.0%) and they would like to receive as much information as possible (86.7%). Oral conversation (83.3%) remained as the preferred method and the clinical pharmacist was preferred by 46.7% of patients as the educator in this aspect. Conclusions: The high prevalence of chemotherapy-related side effects among local patients is of concern. Findings of their perceptions and informational needs may serve as a valuable guide for clinical pharmacists to help in side effect management in Malaysia.

Keywords

References

  1. Aranda S, Jefford M, Yates P, et al. (2012). Impact of a novel nurse-led prechemotherapy education intervention (ChemoEd) on patient distress, symptom burden, and treatment-related information and support needs: results from a randomised, controlled trial. Ann Oncol, 23, 222-31. https://doi.org/10.1093/annonc/mdr042
  2. Ashing-Giwa KT, Lim JW (2009). Examining the impact of socioeconomic status and socioecologic stress on physical and mental health quality of life among breast cancer survivors. Oncol Nurs Forum, 36, 79-88. https://doi.org/10.1188/09.ONF.79-88
  3. Arslan FT, Basbakkal Z, Kantar M (2013). Quality of life and chemotherapy-related symptoms of Turkish cancer children undergoing chemotherapy. Asian Pac J Cancer Prev, 14, 1761-8. https://doi.org/10.7314/APJCP.2013.14.3.1761
  4. Bonnabry P, Cingria L, Ackermann M (2006). Use of a prospective risk analysis method to improve the safety of the cancer chemotherapy process. Int J Qual Health Care, 18, 9-16. https://doi.org/10.1093/intqhc/mzi082
  5. Carelle N, Piotto E, Bellanger A, et al. (2002). Changing patient perceptions of the side effects of cancer chemotherapy. Cancer, 95, 155-63. https://doi.org/10.1002/cncr.10630
  6. Coates A, Abraham S, Kaye SB, et al. (1983). On the receiving end-patient perception of the side-effects of cancer chemotherapy. Eur J Cancer Clin Oncol, 19, 203-8. https://doi.org/10.1016/0277-5379(83)90418-2
  7. Coutsouvelis J, Corallo CE, Dooley MJ, Foo J, Whitfield A (2010). Implementation of a pharmacist - initiated pharmaceutical handover for oncology and haematology patients being transferred to critical care unit. Support Care Cancer, 18, 811-6. https://doi.org/10.1007/s00520-009-0713-4
  8. Dohler N, Krolop L, Ringsdorf S, et al. (2011). Task allocation in cancer medication management - integrating the pharmacist. Patient Educ Couns, 83, 367-74. https://doi.org/10.1016/j.pec.2011.03.002
  9. Farrell C, Brearley SG, Pilling M, Molassiotis A (2013). The impact of chemotherapy-related nausea on patients' nutritional status, psychological distress and quality of life. Support Care Cancer, 21, 59-66. https://doi.org/10.1007/s00520-012-1493-9
  10. Ghandhi TK, Bartel SB, Shulman LN, et al. (2005). Medication safety in the ambulatory chemotherapy setting. Cancer, 104, 2477-83. https://doi.org/10.1002/cncr.21442
  11. Goldspiel BR, DeChristoforo R, Daniels CE (2000). A continuous-improvement approach for reducing the number of chemotherapy-related medication errors. Am J Health Syst Pharm, 57, S4-9.
  12. Griffin AM, Butow PN, Coates AS (1996). On the receiving end. V: Patient perceptions of the side effects of cancer chemotherapy in 1993. Ann Oncol, 7, 189-95.
  13. International Agency sor Research on Cancer (IARC) (2012). Globocan 2012: Estimated cancer incidence, mortality and prevalence worldwide in 2012. Available at http:// globocan.iarc.fr/Pages/fact_sheets_cancer.aspx (last accessed on 30 Jan 2014).
  14. Ismail F, Mohamed AK, Lim KH (2011). Systemic Therapy of Cancer, 3rd edition. The Ministry of Health, Kuala Lumpur pp 75-8.
  15. Jordan K, Schmoll HJ, Aapro MS (2007). Comparative activity of antiemetic drugs. Oncol Hemato, 61, 162-75.
  16. Kayl AE, Meyers CA (2006). Side-effects of chemotherapy and quality of life in ovarian and breast cancer patients. Curr Opin Obstet Gynecol, 18, 24-8. https://doi.org/10.1097/01.gco.0000192996.20040.24
  17. Kessels RP (2003). Patients' memory for medical information. J R Soc Med, 96, 219-22. https://doi.org/10.1258/jrsm.96.5.219
  18. Kim IR, Cho J, Choi EK, et al. (2012). Perception, attitudes, preparedness and experience of chemotherapy-induced alopecia among breast cancer patients: a qualitative study. Asian Pac J Cancer Prev, 13, 1383-8. https://doi.org/10.7314/APJCP.2012.13.4.1383
  19. Lee YM, Francis K, Walker J, Lee SM (2004). What are the information needs of Chinese breast cancer patients receiving chemotherapy? Eur J Oncol Nurs, 8, 224-33. https://doi.org/10.1016/j.ejon.2003.12.006
  20. Lei CP, Har YC, Abdullah KL (2011). Informational needs of breast cancer patients on chemotherapy: differences between patients' and nurses' perceptions. Asian Pac J Cancer Prev, 12, 797-802.
  21. Lemieux J, Maunsell E, Provencher L (2008). Chemotherapy-induced alopecia and effects on quality of life among women with breast cancer: a literature review. Psychooncology, 17, 317-28. https://doi.org/10.1002/pon.1245
  22. Lihara H, Ishihara M, Matsuura K, et al. (2012). Pharmacists contribute to the improve efficiency of medical practices in the outpatient cancer chemotherapy. J Eval Clin Pract, 18, 753-60. https://doi.org/10.1111/j.1365-2753.2011.01665.x
  23. Lopez V, Copp G, Brunton L, Molassiotis A (2011). Symptom experience in patients with gynecological cancers: the development of symptom cIusters through patient narratives. J Support Oncol, 9, 64-71. https://doi.org/10.1016/j.suponc.2011.01.005
  24. Meirow D, Nugent D (2001). The effects of radiotherapy and chemotherapy on female reproduction. Hum Reprod Update, 7, 535-43. https://doi.org/10.1093/humupd/7.6.535
  25. Molassiotis A, Coventry PA, Stricker CT, et al. (2007). Validation and psychometric assessment of a short clinical scale to measure chemotherapy-induced nausea and vomiting: the MASCC antiemesis tool. J Pain Symptom Manage, 34, 148-59. https://doi.org/10.1016/j.jpainsymman.2006.10.018
  26. Naing L, Winn T, Rusli BN (2006). Practical issues in calculating the sample size for prevalence studies. Archiv Orofacial Sci, 1, 9-14.
  27. Partridge AH, Burstein HJ, Winer EP (2001). Side effects of chemotherapy and combined chemohormonal therapy in women with early-stage breast cancer. J Natl Cancer Inst Monogr, 30, 135-42.
  28. Paice JA (2007). Chemotherapy-induced peripheral neuropathy: A dangerous but understudied syndrome. Pain Management SIG Newsletter, 17.
  29. Piredda M, Rocci L, Gualandi R, et al. (2008). Survey on learning needs and preferred sources of information to meet these needs in Italian oncology patients receiving chemotherapy. Eur J Oncol Nurs, 12, 120-6. https://doi.org/10.1016/j.ejon.2007.10.004
  30. Schnell FM (2003). Chemotherapy-induced nausea and vomiting: the importance of acute antiemetic control. Oncologist, 8, 187-98. https://doi.org/10.1634/theoncologist.8-2-187
  31. Shapiro CL, Recht A (2001). Side effects of adjuvant treatment of breast cancer. N Engl J Med, 344, 1997-2008. https://doi.org/10.1056/NEJM200106283442607
  32. Sun CC1, Bodurka DC, Donato ML, et al. (2002). Patient preferences regarding side effects of chemotherapy for ovarian cancer: do they change over time? Gynecol Oncol, 87, 118-28. https://doi.org/10.1006/gyno.2002.6807
  33. Sun CC, Bodurka DC, Weaver CB, et al. (2005). Rankings and symptom assessments of side effects from chemotherapy: insights from experienced patients with ovarian cancer. Support Care Cancer, 13, 219-27 https://doi.org/10.1007/s00520-004-0710-6
  34. Torpy JM, Lynm C, Glass RM (2010). JAMA patient page. Cancer: the basics. JAMA, 303, 1108. https://doi.org/10.1001/jama.303.11.1108
  35. The Ministry of Health, Malaysia (2007). National Cancer Registry Report. Malaysia Cancer Statistics . Data and Figure 2007. Available at http://www.makna.org.my/ PDF/MalaysiaCancerStatistics2007.pdf (last accessed on 30 Jan 2014).
  36. Tuffaha HW, Abdelhadi O, Omar SA (2012). Clinical pharmacy services in the outpatient pediatric oncology clinics at a comprehensive cancer center. Int J Clin Pharm, 34, 27-31. https://doi.org/10.1007/s11096-011-9600-4
  37. Valgus JM, Faso A, Gregory KM, et al (2011). Integration of a clinical pharmacist into the hematology-oncology clinics at an academic medical center. Am J Health Syst Pharm, 68, 613-9. https://doi.org/10.2146/ajhp100414

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