Journal of Korean Society of Occupational and Environmental Hygiene (한국산업보건학회지)

Korean Industrial Hygiene Association (한국산업보건학회)
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Effect of Korean Chrysotile on the Lung Function of Rats

한국산 백석면이 랫드의 폐 기능에 미치는 영향 평가 연구

  • Chung, Yong Hyun (Toxicity Research Team, Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) ;
  • Kang, Min Gu (Toxicity Research Team, Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) ;
  • Han, Jeong Hee (Toxicity Research Team, Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency)
  • 정용현 (산업안전보건연구원 독성연구팀) ;
  • 강민구 (산업안전보건연구원 독성연구팀) ;
  • 한정희 (산업안전보건연구원 독성연구팀)
  • Received : 2014.04.04
  • Accepted : 2014.05.22
  • Published : 2014.06.30
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Abstract

Objectives: To evaluate the pulmonary toxicity of Korean Chrysotile(KC), the lung function and the number of fibers in the bronchoalveolar lavage fluid of Sprague-Dawley rats instilled with KC were estimated. Materials: Rats were administered 1 mg KC by a single intratracheal instillation. At each time point(5 days, 5 weeks, 10 weeks), the lung function of the rats was analyzed by pressure transducer and the amount of asbestos in the bronchoalveolar lavage fluid of the rats was calculated by transmission electron microscope equipped with energy dispersive X-ray spectrometer. Results: The lung function of the rats at 5 days after instillation of KC was confirmed to be degraded. However, after 5 weeks the test groups showed a tendency to recover lung function. Still, after 10 weeks the lung function of the test groups had not recovered completely. The number of fibers in the bronchoalveolar lavage fluid of the rats instilled with KC rapidly decreased. At 5 weeks the number of fibers had reduced to approximately 1/2 of that found at 5 days. Over time, at 10 weeks it had rapidly decreased to 1/100 that found at 5 days. Conclusions: Korean chrysotile fibers rapidly decreased in the lungs of rats, but the lung function of rats instilled KC does had not completely recovered by 10 weeks.

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References

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