DOI QR코드

DOI QR Code

Diagnosis of Trace Toxic Uranium Ions in Organic Liver Cell

  • Ly, Suw Young (Biosensor Biosensor Research Institute, Seoul National University of Technology) ;
  • Pack, Eun Chul (Department of Public Health Science, Graduate School, Korea University) ;
  • Choi, Dal Woong (Department of Public Health Science, Graduate School, Korea University)
  • 투고 : 2014.03.28
  • 심사 : 2014.06.30
  • 발행 : 2014.06.30

초록

Uranium is toxic and radioactive traces of it can be found in natural water and soils. High concentrations of it in biological systems cause genetic disorders and diseases. For the in vivo diagnosis, micro and nano range detection limits are required. Here, an electrochemical assay for trace toxic uranium was searched using stripping voltammetry. Renewable and simplified graphite pencils electrode (PE) was used in a three-electrode cell system. Seawater was used instead of an electrolyte solution. This setup can yield good results and the detection limit was attained to be at $10{\mu}gL^{-1}$. The developed skill can be applied to organic liver cell.

키워드

참고문헌

  1. Jaspal, S., Lakhwant, S. and Sanjay, K. (2003) A comparison of fission track and laser fluorometry techniques for uranium analysis in water samples. Radiat. Meas., 36, 517-519. https://doi.org/10.1016/S1350-4487(03)00193-8
  2. Becker, J.S., Dobrowolska, J., Zoriy, M. and Matusch, A. (2008) Imaging of uranium on rat brain sections using laser ablation inductively coupled plasma mass spectrometry: a new tool for the study of critical substructures affined to heavy metals in tissues. Rapid Commun. Mass Spectrom., 22, 2768-2772. https://doi.org/10.1002/rcm.3673
  3. Metilda, P., Prasad, K., Kala, R., Gladis, J.M., Rao, T.P. and Naidu, G.R. (2007) Ion imprinted polymer based sensor for monitoring toxic uranium in environmental samples. Anal. Chim. Acta, 582, 147-153. https://doi.org/10.1016/j.aca.2006.08.052
  4. Bellis, D., Ma, R., Bramall, N., McLeod, C.W., Chapman, N. and Satake, K. (2001) Airborne uranium contamination - as revealed through elemental and isotopic analysis of tree bark. Environ. Pollut., 114, 383-387. https://doi.org/10.1016/S0269-7491(00)00236-0
  5. Kurttio, P., Harmoinen, A., Saha, H., Salonen, L., Karpas, Z., Komulainen, H. and Auvinen, A. (2006) Kidney toxicity of ingested uranium from drinking water. Am. J. Kidney Dis., 47, 972-982. https://doi.org/10.1053/j.ajkd.2006.03.002
  6. Burkart, W., Danesi, P.R. and Hendry, J.H. (2005) Properties, use and health effects of depleted uranium. Int. Congr. Ser., 1276, 133-136. https://doi.org/10.1016/j.ics.2004.09.047
  7. Linares, V., Albina, M.L., Belles, M., Mayayo, E., Sanchez, D.J. and Domingo, J.L. (2005) Combined action of uranium and stress in the rat. II. Effects on male reproduction. Toxicol. Lett., 158, 186-195. https://doi.org/10.1016/j.toxlet.2005.03.015
  8. Hedaya, M.A., Birkenfeld, H.P. and Kathren, R.L. (1997) A sensitive method for the determination of uranium in biological samples utilizing kinetic phosphorescence analysis (KPA). J. Pharm. Biomed., 15, 1157-1165. https://doi.org/10.1016/S0731-7085(96)01957-7
  9. Ejnik, J.W., Hamilton, M.M., Adams, P.R. and Carmichael, A.J. (2000) Optimal sample preparation conditions for the determination of uranium in biological samples by kinetic phosphorescence analysis (KPA). J. Pharm. Biomed., 24, 227-235. https://doi.org/10.1016/S0731-7085(00)00412-X
  10. Yucel, H. (2007) The applicability of MGA method for depleted and natural uranium isotopic analysis in the presence of actinides (232Th, 237Np, 233Pa and 241Am). Appl. Radiat. Isot., 65, 1269-1280. https://doi.org/10.1016/j.apradiso.2007.05.007
  11. Degueldre, C., Favarger, P.Y., Rosse, R. and Wold, S. (2006) Uranium colloid analysis by single particle inductively coupled plasma-mass spectrometry. Talanta, 68, 623-628. https://doi.org/10.1016/j.talanta.2005.05.006
  12. Lee, M.H. and Lee, C.W. (2001) Radiochemical analysis of uranium isotopes in soil and sediment samples with extraction chromatography. Talanta, 54, 181-186. https://doi.org/10.1016/S0039-9140(00)00666-4
  13. Rubio Montero, M.P., Martin Sanchez, A. and Carrasco Lourtau, A.M. (2004) Isotopic uranium and plutonium analysis by alpha-particle spectrometry. Nucl. Instrum. Methods B, 213, 429-433. https://doi.org/10.1016/S0168-583X(03)01585-4
  14. Carriere, M., Gouget, B., Gallien, J.P., Avoscan, L., Gobin, R., Verbavatz, J.M. and Khodja, H. (2005) Cellular distribution of uranium after acute exposure of renal epithelial cells: SEM, TEM and nuclear microscopy analysis. Nucl. Instrum. Methods B, 231, 268-273. https://doi.org/10.1016/j.nimb.2005.01.069
  15. Meinrath, G. (1998) Chemometric analysis: Uranium (VI) hydrolysis by UV-Vis spectroscopy. J. Alloys Compd., 275, 777-781.
  16. Karbowiak, M., Droodoynski, J. and Gajek, Z. (2001) Absorption spectrum analysis of uranium trichloride heptahydrate. J. Alloys Compd., 323, 678-682.
  17. Pajo, L., Tamborini, G., Rasmussen, G., Mayer, K. and Koch, L. (2001) A novel isotope analysis of oxygen in uranium oxides: comparison of secondary ion mass spectrometry, glow discharge mass spectrometry and thermal ionization mass spectrometry. Spectrochim. Acta B, 56, 541-549. https://doi.org/10.1016/S0584-8547(01)00219-1
  18. Wittmaack, K. (2008) SIMS analysis of xenon and krypton in uranium dioxide: A comparison of two models of gas-phase ionization. Nucl. Instrum. Methods B, 266, 5151-5158. https://doi.org/10.1016/j.nimb.2008.09.018
  19. Soldatov, A.V., Lamoen, D., Konstantinovic, M.J., Van den Berghe, S., Scheinost, A.C. and Verwerft, M. (2007) Local structure and oxidation state of uranium in some ternary oxides: X-ray absorption analysis. J. Solid State Chem., 180, 54-61. https://doi.org/10.1016/j.jssc.2006.08.038
  20. Pournaghi, M.H. and Zargharian, R. (1996) Adsorptive pulse polarographic determination of uranium(V1) oxinate in chloroform and its use for the analysis of uranium mineral ores. Anal. Chim. Acta, 328, 33-39. https://doi.org/10.1016/0003-2670(96)00064-5
  21. Sander, S., Wagner, W. and Henze, G. (1997) Possibilities uranium for the automated determination of trace concentrations of in water samples by adsorptive stripping voltammetry. Anal. Chim. Acta, 349, 93-99. https://doi.org/10.1016/S0003-2670(96)00591-0
  22. Sander, S., Wagner, W. and Henze, G. (1995) Direct determination of uranium traces by adsorptive stripping voltammetry. Anal. Chim. Acta, 305, 154-158. https://doi.org/10.1016/0003-2670(94)00481-Z
  23. Gholivand, M.B., Nassab, H.R. and Fazeli, H. (2005) Cathodic adsorptive stripping voltammetric determination of uranium (VI) complexed with 2, 6-pyridinedicarboxylic acid. Talanta, 65, 62-66. https://doi.org/10.1016/j.talanta.2004.05.019
  24. Farghaly, O.A. and Ghandour, M.A. (1999) Cathodic adsorptive stripping voltammetric determination of uranium with potassium hydrogen phthalate. Talanta, 49, 31-40. https://doi.org/10.1016/S0039-9140(98)00338-5