Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Air Pollution Exposure and Cardiovascular Disease

  • Lee, Byeong-Jae (Inhalation Toxicology Research Center, Korea Institute of Toxicology) ;
  • Kim, Bumseok (Biosafety Research Institute and Laboratory of Pathology, College of Veterinary Medicine, Chonbuk National University) ;
  • Lee, Kyuhong (Inhalation Toxicology Research Center, Korea Institute of Toxicology)
  • Received : 2014.06.19
  • Accepted : 2014.06.27
  • Published : 2014.06.30
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Abstract

Ambient air pollution (AAP) and particulate matters (PM) have been closely associated with adverse health effects such as respiratory disease and cardiovascular diseases. Previous studies have examined the adverse health effects associated with short- and long-term exposure to AAP and outdoor PM on respiratory disease. However, the effect of PM size ($PM_{2.5}$ and $PM_{10}$) on cardiovascular disease has not been well studied. Thus, it remains unclear how the size of the inhalable particles (coarse, fine, or ultrafine) affects mortality and morbidity. Airborne PM concentrations are commonly used for ambient air quality management worldwide, owing to the known effects on cardiorespiratory health. In this article, we assess the relationship between cardiovascular diseases and PM, with a particular focus on PM size. We discuss the association of $PM_{2.5}$ and $PM_{10}$, nitrogen dioxide ($NO_2$), and elemental carbon with mortality and morbidity due to cardiovascular diseases, stroke, and altered blood pressure, based on epidemiological studies. In addition, we provide evidence that the adverse health effects of AAP and PM are more pronounced among the elderly, children, and people with preexisting cardiovascular and respiratory conditions. Finally, we critically summarize the literature pertaining to cardiovascular diseases, including atherosclerosis and stroke, and introduce potential studies to better understand the health significance of AAP and PM on cardiovascular disease.

Keywords

References

  1. WHO. (2006) WHO's global air-quality guidelines. Lancet, 368, 1302.
  2. Marks, G.B. (1994) A critical appraisal of the evidence for adverse respiratory effects due to exposure to environmental ozone and particulate pollution: relevance to air quality guidelines. Aust. N. Z. J. Med., 24, 202-213. https://doi.org/10.1111/j.1445-5994.1994.tb00558.x
  3. Dockery, D.W., Pope, C.A. 3rd., Xu, X., Spengler, J.D., Ware, J.H., Fay, M.E., Ferris, B.G. Jr. and Speizer, F.E. (1993) An association between air pollution and mortality in six U.S. cities. N. Engl. J. Med., 329, 1753-1759. https://doi.org/10.1056/NEJM199312093292401
  4. Hoek, G., Brunekreef, B., Goldbohm, S., Fischer, P. and van den Brandt, P.A. (2002) Association between mortality and indicators of traffic-related air pollution in the Netherlands: a cohort study. Lancet, 360, 1203-1209. https://doi.org/10.1016/S0140-6736(02)11280-3
  5. Pope, C.A. 3rd, Burnett, R.T., Thurston, G.D., Thun, M.J., Calle, E.E., Krewski, D. and Godleski, J.J. (2004) Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease. Circulation, 109, 71-77.
  6. Brunekreef, B. and Holgate, S.T. (2002) Air pollution and health. Lancet, 360, 1233-1242. https://doi.org/10.1016/S0140-6736(02)11274-8
  7. Brook, R.D., Franklin, B., Cascio, W., Hong, Y., Howard, G., Lipsett, M., Luepker, R., Mittleman, M., Samet, J., Smith, S.C. Jr. and Tager, I. (2004) Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association. Circulation, 109, 2655-2671. https://doi.org/10.1161/01.CIR.0000128587.30041.C8
  8. Hoek, G., Brunekreef, B., Fischer, P. and van Wijnen, J. (2001) The association between air pollution and heart failure, arrhythmia, embolism, thrombosis, and other cardiovascular causes of death in a time series study. Epidemiology, 12, 355-357. https://doi.org/10.1097/00001648-200105000-00017
  9. Pope, C.A., 3rd, Thun, M.J., Namboodiri, M.M., Dockery, D.W., Evans, J.S., Speizer, F.E. and Heath, C.W. Jr. (1995) Particulate air pollution as a predictor of mortality in a prospective study of U.S. adults. Am. J. Respir. Crit. Care Med., 151, 669-674. https://doi.org/10.1164/ajrccm/151.3_Pt_1.669
  10. Samet, J.M., Dominici, F., Curriero, F.C., Coursac, I. and Zeger, S.L. (2000) Fine particulate air pollution and mortality in 20 U.S. cities, 1987-1994. N. Engl. J. Med., 343, 1742-1749. https://doi.org/10.1056/NEJM200012143432401
  11. Peters, A., Dockery, D.W., Muller, J.E. and Mittleman, M.A. (2001) Increased particulate air pollution and the triggering of myocardial infarction. Circulation, 103, 2810-2815. https://doi.org/10.1161/01.CIR.103.23.2810
  12. Shah, A.S., Langrish, J.P., Nair, H., McAllister, D.A., Hunter, A.L., Donaldson, K., Newby, D.E. and Mills, N.L. (2013) Global association of air pollution and heart failure: a systematic review and meta-analysis. Lancet, 382, 1039-1048. https://doi.org/10.1016/S0140-6736(13)60898-3
  13. Franchini, M. and Mannucci, P.M. (2009) Particulate air pollution and cardiovascular risk: short-term and long-term effects. Semin. Thromb. Hemostasis, 35, 665-670. https://doi.org/10.1055/s-0029-1242720
  14. Franchini, M. and Mannucci, P.M. (2007) Short-term effects of air pollution on cardiovascular diseases: outcomes and mechanisms. J. Thromb. Haemostasis, 5, 2169-2174. https://doi.org/10.1111/j.1538-7836.2007.02750.x
  15. Nawrot, T.S., Perez, L., Kunzli, N., Munters, E. and Nemery, B. (2011) Public health importance of triggers of myocardial infarction: a comparative risk assessment. Lancet, 377, 732-740. https://doi.org/10.1016/S0140-6736(10)62296-9
  16. Brown, J.S., Zeman, K.L. and Bennett, W.D. (2002) Ultrafine particle deposition and clearance in the healthy and obstructed lung. Am. J. Respir. Crit. Care Med., 166, 1240-1247. https://doi.org/10.1164/rccm.200205-399OC
  17. Franck, U., Odeh, S., Wiedensohler, A., Wehner, B. and Herbarth, O. (2011) The effect of particle size on cardiovascular disorders--the smaller the worse. Sci. Total Environ., 409, 4217-4221. https://doi.org/10.1016/j.scitotenv.2011.05.049
  18. Valavanidis, A., Fiotakis, K. and Vlachogianni, T. (2008) Airborne particulate matter and human health: toxicological assessment and importance of size and composition of particles for oxidative damage and carcinogenic mechanisms. J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev., 26, 339-362. https://doi.org/10.1080/10590500802494538
  19. Mills, N.L., Amin, N., Robinson, S.D., Anand, A., Davies, J., Patel, D., de la Fuente, J.M., Cassee, F.R., Boon, N.A., Macnee, W., Millar, A.M., Donaldson, K. and Newby, D.E. (2006) Do inhaled carbon nanoparticles translocate directly into the circulation in humans? Am. J. Respir. Crit. Care Med., 173, 426-431. https://doi.org/10.1164/rccm.200506-865OC
  20. Nemmar, A., Vanbilloen, H., Hoylaerts, M.F., Hoet, P.H., Verbruggen, A. and Nemery, B. (2001) Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster. Am. J. Respir. Crit. Care Med., 164, 1665-1668. https://doi.org/10.1164/ajrccm.164.9.2101036
  21. Franchini, M. and Mannucci, P.M. (2011) Thrombogenicity and cardiovascular effects of ambient air pollution. Blood, 118, 2405-2412. https://doi.org/10.1182/blood-2011-04-343111
  22. Langrish, J.P., Bosson, J., Unosson, J., Muala, A., Newby, D.E., Mills, N.L., Blomberg, A. and Sandstrom, T. (2012) Cardiovascular effects of particulate air pollution exposure: time course and underlying mechanisms. J. Intern. Med., 272, 224-239. https://doi.org/10.1111/j.1365-2796.2012.02566.x
  23. Analitis, A., Katsouyanni, K., Dimakopoulou, K., Samoli, E., Nikoloulopoulos, A.K., Petasakis, Y., Touloumi, G., Schwartz, J., Anderson, H.R., Cambra, K., Forastiere, F., Zmirou, D., Vonk, J.M., Clancy, L., Kriz, B., Bobvos, J. and Pekkanen, J. (2006) Short-term effects of ambient particles on cardiovascular and respiratory mortality. Epidemiology, 17, 230-233. https://doi.org/10.1097/01.ede.0000199439.57655.6b
  24. Laden, F., Schwartz, J., Speizer, F.E. and Dockery, D.W. (2006) Reduction in fine particulate air pollution and mortality: Extended follow-up of the Harvard Six Cities study. Am. J. Respir. Crit. Care Med., 173, 667-672. https://doi.org/10.1164/rccm.200503-443OC
  25. Lepeule, J., Laden, F., Dockery, D. and Schwartz, J. (2012) Chronic exposure to fine particles and mortality: an extended follow-up of the Harvard Six Cities study from 1974 to 2009. Environ. Health Perspect., 120, 965-970. https://doi.org/10.1289/ehp.1104660
  26. Gold, D.R., Litonjua, A., Schwartz, J., Lovett, E., Larson, A., Nearing, B., Allen, G., Verrier, M., Cherry, R. and Verrier, R. (2000) Ambient pollution and heart rate variability. Circulation, 101, 1267-1273. https://doi.org/10.1161/01.CIR.101.11.1267
  27. Wellenius, G.A., Schwartz, J. and Mittleman, M.A. (2006) Particulate air pollution and hospital admissions for congestive heart failure in seven United States cities. Am. J. Cardiol., 97, 404-408. https://doi.org/10.1016/j.amjcard.2005.08.061
  28. Zanobetti, A. and Schwartz, J. (2005) The effect of particulate air pollution on emergency admissions for myocardial infarction: a multicity case-crossover analysis. Environ. Health Perspect., 113, 978-982. https://doi.org/10.1289/ehp.7550
  29. Pope, C.A. 3rd., Muhlestein, J.B., May, H.T., Renlund, D.G., Anderson, J.L. and Horne, B.D. (2006) Ischemic heart disease events triggered by short-term exposure to fine particulate air pollution. Circulation, 114, 2443-2448. https://doi.org/10.1161/CIRCULATIONAHA.106.636977
  30. Brook, R.D. (2008) Cardiovascular effects of air pollution. Clin. Sci. (Lond), 115, 175-187. https://doi.org/10.1042/CS20070444
  31. Brook, R.D., Brook, J.R. and Rajagopalan, S. (2003) Air pollution: the "Heart" of the problem. Curr. Hypertens. Rep., 5, 32-39. https://doi.org/10.1007/s11906-003-0008-y
  32. Zanobetti, A., Schwartz, J., Samoli, E., Gryparis, A., Touloumi, G., Peacock, J., Anderson, R.H., Le, T.A., Bobros, J., Celko, M., Goren, A., Forsberg, B., Michelozzi, P., Rabczenko, D., Hoyos, S.P., Wichmann, H.E. and Katsouyanni, K. (2003) The temporal pattern of respiratory and heart disease mortality in response to air pollution. Environ. Health Perspect., 111, 1188-1193. https://doi.org/10.1289/ehp.5712
  33. Morris, R.D. (2001) Airborne particulates and hospital admissions for cardiovascular disease: a quantitative review of the evidence. Environ. Health Perspect., 109 Suppl 4, 495-500. https://doi.org/10.1289/ehp.01109s4495
  34. Low, R.B., Bielory, L., Qureshi, A.I., Dunn, V., Stuhlmiller, D.F. and Dickey, D.A. (2006) The relation of stroke admissions to recent weather, airborne allergens, air pollution, seasons, upper respiratory infections, and asthma incidence, September 11, 2001, and day of the week. Stroke, 37, 951-957. https://doi.org/10.1161/01.STR.0000214681.94680.66
  35. Dominici, F., Peng, R.D., Bell, M.L., Pham, L., McDermott, A., Zeger, S.L. and Samet, J.M. (2006) Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases. JAMA, 295, 1127-1134. https://doi.org/10.1001/jama.295.10.1127
  36. Brook, R.D. (2007) Why physicians who treat hypertension should know more about air pollution. J. Clin. Hypertens. (Greenwich), 9, 629-635. https://doi.org/10.1111/j.1524-6175.2007.07187.x
  37. Urch, B., Silverman, F., Corey, P., Brook, J.R., Lukic, K.Z., Rajagopalan, S. and Brook, R.D. (2005) Acute blood pressure responses in healthy adults during controlled air pollution exposures. Environ. Health Perspect., 113, 1052-1055. https://doi.org/10.1289/ehp.7785
  38. de Paula, S.U., Braga, A.L., Giorgi, D.M., Pereira, L.A., Grupi, C.J., Lin, C.A., Bussacos, M.A., Zanetta, D.M., do Nascimento Saldiva, P.H. and Filho, M.T. (2005) Effects of air pollution on blood pressure and heart rate variability: a panel study of vehicular traffic controllers in the city of Sao Paulo, Brazil. Eur. Heart J., 26, 193-200. https://doi.org/10.1093/eurheartj/ehi035
  39. Dubowsky, S.D., Suh, H., Schwartz, J., Coull, B.A. and Gold, D.R. (2006) Diabetes, obesity, and hypertension may enhance associations between air pollution and markers of systemic inflammation. Environ. Health Perspect., 114, 992-998. https://doi.org/10.1289/ehp.8469
  40. Peel, J.L., Metzger, K.B., Klein, M., Flanders, W.D., Mulholland, J.A. and Tolbert, P.E. (2007) Ambient air pollution and cardiovascular emergency department visits in potentially sensitive groups. Am. J. Epidemiol., 165, 625-633. https://doi.org/10.1093/aje/kwk051

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