한국지능시스템학회논문지 (Journal of the Korean Institute of Intelligent Systems)

  • 제24권3호
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  • Pages.251-258
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  • 2014
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  • 1976-9172(pISSN)
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  • 2288-2324(eISSN)
한국지능시스템학회 (Korean Institute of Intelligent Systems)
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시간 경과 신경계 영상 시퀀스에서의 축삭돌기 추출 기법

An Automated Technique for Detecting Axon Structure in Time-Lapse Neural Image Sequence

  • 김낙현 (한국외국어대학교 디지털정보공학과)
  • Kim, Nak Hyun (Department of Digital Information Engineering, Hankuk University of Foreign Studies)
  • 투고 : 2014.03.13
  • 심사 : 2014.04.16
  • 발행 : 2014.06.25
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초록

신경계 영상 해석의 목적은 움직이는 미토콘드리아들을 추적하여 그 속도와 이동 방향 등을 추출하는 것인데, 미토콘드리아의 움직임은 축삭돌기 상에서만 이루어지는 특징이 있다. 축삭돌기 추출 작업은 일반적으로 수작업을 동반한 처리 과정을 통해 이루어지고 있는데, 본 논문에서는 자동화된 축삭돌기 추출 기법을 제안한다. 우선 전체 비디오 프레임 영상에서 각 픽셀의 최대값을 취해 통합영상을 구한다. 통합 영상에서 축삭돌기는 능선 구조를 보이는데, 능선을 검출하기 위해 본 연구에서는 능선 강화 필터링과 피크 검출 과정을 적용하였다. 또한 검출된 능선점에서 나타난 오류를 제거하기 위해 대해 각 능선점 주위에서 신뢰도 함수를 사용한 필터링을 적용한다. 실제 영상을 이용한 실험을 통해 제안된 방식은 높은 검출률과 정확도를 나타내는 것을 확인하였다.

The purpose of the neural image analysis is to trace the velocities and the directions of moving mitochondria migrating through axons. This paper proposes an automated technique for detecting axon structure. Previously, the detection process has been carried out using a partially automated technique combined with some human intervention. In our algorithm, a consolidated image is built by taking the maximum intensity value on the all image frames at each pixel Axon detection is performed through vessel enhancement filtering followed by a peak detection procedure. In order to remove errors contained in ridge points, a filtering process is devised using a local reliability measure. Experiments have been performed using real neural image sequences and ground truth data extracted manually. It has been turned out that the proposed algorithm results in high detection rate and precision.

키워드

참고문헌

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