Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Prevalence of respiratory viral infection in children hospitalized for acute lower respiratory tract diseases, and association of rhinovirus and influenza virus with asthma exacerbations

  • Kwon, Jang-Mi (Department of Pediatrics, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Shim, Jae Won (Department of Pediatrics, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Deok Soo (Department of Pediatrics, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Jung, Hye Lim (Department of Pediatrics, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Park, Moon Soo (Department of Pediatrics, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Shim, Jung Yeon (Department of Pediatrics, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • Received : 2013.02.02
  • Accepted : 2013.04.14
  • Published : 2014.01.15
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Abstract

Purpose: In this study, we aimed to investigate the prevalence of year-round respiratory viral infection in children with lower respiratory tract infection (LRTI) and the relationship between respiratory viral infection and allergen sensitization in exacerbating asthma. Methods: We investigated the sources for acute LRTIs in children admitted to our hospital from May 2010 to April 2011. The 6 most common respiratory viruses were isolated from nasopharyngeal aspirate using multiplex reverse transcription-polymerase chain reaction in 309 children; respiratory syncytial virus (RSV), adenovirus (AV), parainfluenza virus (PIV), influenza virus (IFV), human metapneumovirus (hMPV), rhinovirus (RV). Atopic sensitization was defined if more than 1 serum specific Immunoglobulin E level measured using UniCAP (Pharmacia) was over 0.35 IU/mL. Results: RSV was the most common pathogen of bronchiolitis in hospitalized children through the year. RV or IFV infection was more prevalent in asthma exacerbations compared to other LRTIs. AV and hMPV were more likely to cause pneumonia. RV and IFV were associated with asthma exacerbations in children with atopic sensitization, but not in nonatopic children. Conclusion: RV and IFV are associated with hospitalization for asthma exacerbation in children with atopic sensitization.

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References

  1. Ruuskanen O, Lahti E, Jennings LC, Murdoch DR. Viral pneumonia. Lancet 2011;377:1264-75. https://doi.org/10.1016/S0140-6736(10)61459-6
  2. Bosis S, Esposito S, Niesters HG, Zuccotti GV, Marseglia G, Lanari M, et al. Role of respiratory pathogens in infants hospitalized for a first episode of wheezing and their impact on recurrences. Clin Microbiol Infect 2008;14:677-84. https://doi.org/10.1111/j.1469-0691.2008.02016.x
  3. Masoli M, Fabian D, Holt S, Beasley R; Global Initiative for Asthma (GINA) Program. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 2004;59: 469-78. https://doi.org/10.1111/j.1398-9995.2004.00526.x
  4. Cypcar D, Stark J, Lemanske RF Jr. The impact of respiratory infections on asthma. Pediatr Clin North Am 1992;39:1259-76. https://doi.org/10.1016/S0031-3955(16)38444-9
  5. Grünberg K, Smits HH, Timmers MC, de Klerk EP, Dolhain RJ, Dick EC, et al. Experimental rhinovirus 16 infection. Effects on cell differentials and soluble markers in sputum in asthmatic subjects. Am J Respir Crit Care Med 1997;156(2 Pt 1):609-16. https://doi.org/10.1164/ajrccm.156.2.9610079
  6. Murray CS, Simpson A, Custovic A. Allergens, viruses, and asthma exacerbations. Proc Am Thorac Soc 2004;1:99-104. https://doi.org/10.1513/pats.2306027
  7. Tan WC. Viruses in asthma exacerbations. Curr Opin Pulm Med 2005;11:21-6.
  8. Tsitoura DC, Kim S, Dabbagh K, Berry G, Lewis DB, Umetsu DT. Respiratory infection with influenza A virus interferes with the induction of tolerance to aeroallergens. J Immunol 2000;165:3484-91. https://doi.org/10.4049/jimmunol.165.6.3484
  9. Suzuki S, Suzuki Y, Yamamoto N, Matsumoto Y, Shirai A, Okubo T. Influenza A virus infection increases IgE production and airway responsiveness in aerosolized antigen-exposed mice. J Allergy Clin Immunol 1998;102:732-40. https://doi.org/10.1016/S0091-6749(98)70012-0
  10. Schwarze J, Gelfand EW. Respiratory viral infections as promoters of allergic sensitization and asthma in animal models. Eur Respir J 2002;19:341-9. https://doi.org/10.1183/09031936.02.00254302
  11. Murray CS, Poletti G, Kebadze T, Morris J, Woodcock A, Johnston SL, et al. Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children. Thorax 2006;61:376-82. https://doi.org/10.1136/thx.2005.042523
  12. Green RM, Custovic A, Sanderson G, Hunter J, Johnston SL, Woodcock A. Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study. BMJ 2002; 324:763.
  13. Jartti T, Kuusipalo H, Vuorinen T, Soderlund-Venermo M, Allander T, Waris M, et al. Allergic sensitization is associated with rhinovirus-, but not other virus-, induced wheezing in children. Pediatr Allergy Immunol 2010;21:1008-14. https://doi.org/10.1111/j.1399-3038.2010.01059.x
  14. Denny FW, Clyde WA Jr. Acute lower respiratory tract infections in nonhospitalized children. J Pediatr 1986;108(5 Pt 1):635-46. https://doi.org/10.1016/S0022-3476(86)81034-4
  15. Knutson D, Braun C. Diagnosis and management of acute bronchitis. Am Fam Physician 2002;65:2039-44.
  16. Pedersen SE, Hurd SS, Lemanske RF Jr, Becker A, Zar HJ, Sly PD, et al. Global strategy for the diagnosis and management of asthma in children 5 years and younger. Pediatr Pulmonol 2011;46:1-17.
  17. Jartti T, Lehtinen P, Vuorinen T, Osterback R, van den Hoogen B, Osterhaus AD, et al. Respiratory picornaviruses and respiratory syncytial virus as causative agents of acute expiratory wheezing in children. Emerg Infect Dis 2004;10:1095-101. https://doi.org/10.3201/eid1006.030629
  18. Lim JS, Woo SI, Kwon HI, Baek YH, Choi YK, Hahn YS. Clinical characteristics of acute lower respiratory tract infections due to 13 respiratory viruses detected by multiplex PCR in children. Korean J Pediatr 2010;53:373-9. https://doi.org/10.3345/kjp.2010.53.3.373
  19. Caracciolo S, Minini C, Colombrita D, Rossi D, Miglietti N, Vettore E, et al. Human metapneumovirus infection in young children hospitalized with acute respiratory tract disease: virologic and clinical features. Pediatr Infect Dis J 2008;27:406-12. https://doi.org/10.1097/INF.0b013e318162a164
  20. Williams JV, Harris PA, Tollefson SJ, Halburnt-Rush LL, Pingsterhaus JM, Edwards KM, et al. Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N Engl J Med 2004;350:443-50. https://doi.org/10.1056/NEJMoa025472
  21. Choi EH, Lee HJ, Kim SJ, Eun BW, Kim NH, Lee JA, et al. The association of newly identified respiratory viruses with lower respiratory tract infections in Korean children, 2000-2005. Clin Infect Dis 2006;43:585-92. https://doi.org/10.1086/506350
  22. Kim HY, Kim KM, Kim SH, Son SK, Park HJ. Clinical manifestations of respiratory viruses in hospitalized children with acute viral lower respiratory tract infections from 2010 to 2011 in Busan and Gyeongsangnam-do, Korea. Pediatr Allergy Respir Dis 2012;22:265-72. https://doi.org/10.7581/pard.2012.22.3.265
  23. Rakes GP, Arruda E, Ingram JM, Hoover GE, Zambrano JC, Hayden FG, et al. Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care. IgE and eosinophil analyses. Am J Respir Crit Care Med 1999;159:785-90. https://doi.org/10.1164/ajrccm.159.3.9801052
  24. Kato M, Tsukagoshi H, Yoshizumi M, Saitoh M, Kozawa K, Yamada Y, et al. Different cytokine profile and eosinophil activation are involved in rhinovirus- and RS virus-induced acute exacerbation of childhood wheezing. Pediatr Allergy Immunol 2011;22(1 Pt 2): e87-94. https://doi.org/10.1111/j.1399-3038.2010.01026.x
  25. Cheuk DK, Tang IW, Chan KH, Woo PC, Peiris MJ, Chiu SS. Rhinovirus infection in hospitalized children in Hong Kong: a prospective study. Pediatr Infect Dis J 2007;26:995-1000. https://doi.org/10.1097/INF.0b013e3181586b63
  26. Kusel MM, de Klerk NH, Kebadze T, Vohma V, Holt PG, Johnston SL, et al. Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J Allergy Clin Immunol 2007;119:1105-10. https://doi.org/10.1016/j.jaci.2006.12.669
  27. Olenec JP, Kim WK, Lee WM, Vang F, Pappas TE, Salazar LE, et al. Weekly monitoring of children with asthma for infections and illness during common cold seasons. J Allergy Clin Immunol 2010; 125:1001-1006.e1. https://doi.org/10.1016/j.jaci.2010.01.059
  28. Kelly JT, Busse WW. Host immune responses to rhinovirus: mechanisms in asthma. J Allergy Clin Immunol 2008;122:671-82. https://doi.org/10.1016/j.jaci.2008.08.013
  29. Bianco A, Sethi SK, Allen JT, Knight RA, Spiteri MA. Th2 cytokines exert a dominant influence on epithelial cell expression of the major group human rhinovirus receptor, ICAM-1. Eur Respir J 1998;12:619-26. https://doi.org/10.1183/09031936.98.12030619
  30. Yamamoto N, Suzuki S, Shirai A, Suzuki M, Nakazawa M, Nagashima Y, et al. Dendritic cells are associated with augmentation of antigen sensitization by influenza A virus infection in mice. Eur J Immunol 2000;30:316-26. https://doi.org/10.1002/1521-4141(200001)30:1<316::AID-IMMU316>3.0.CO;2-0
  31. Kloepfer KM, Olenec JP, Lee WM, Liu G, Vrtis RF, Roberg KA, et al. Increased H1N1 infection rate in children with asthma. Am J Respir Crit Care Med 2012;185:1275-9. https://doi.org/10.1164/rccm.201109-1635OC
  32. Kim YJ, Ryu SL, Jung SH, Shim JW, Kim DS, Jung HL, et al. Increased prevalence of H1N1-induced severe lower respiratory tract diseases in children with atopic sensitization. Allergy Asthma Immunol Res 2012;4:277-83. https://doi.org/10.4168/aair.2012.4.5.277

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