Polymer(Korea) (폴리머)

The Polymer Society of Korea (한국고분자학회)
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Electrospinning of Asiaticoside/2-Hydroxypropyl-β-cyclodextrin Inclusion Complex-loaded Cellulose Acetate Fiber Mats: Release Characteristics and Potential for Use as Wound Dressing

Asiaticoside/2-Hydroxypropyl-β-cyclodextrin 포접화합물 함유 셀룰로오스 아세테이트 섬유 매트의 전기방사: 창상피복제로서 사용가능성과 방출특성

  • Panichpakdee, Jate (The Petroleum and Petrochemical College, Chulalongkorn University) ;
  • Pavasant, Prasit (Department of Anatomy, Faculty of Dentistry, Chulalongkorn University) ;
  • Supaphol, Pitt (The Petroleum and Petrochemical College, Chulalongkorn University)
  • Received : 2013.11.12
  • Accepted : 2014.02.12
  • Published : 2014.05.25
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Abstract

Cellulose acetate (CA) fiber mats containing inclusion complexes of asiaticoside (AC) in 2-hydroxypropyl-${\beta}$-cyclodextrin ($HP{\beta}CD$) for potential usage as wound dressings were developed. The AC/$HP{\beta}CD$ complex-loaded CA fibers at various $HP{\beta}CD$ to AC molar ratios of 0.5, 1, and 2 were prepared in 90:10 v/v mixture of 80% (v/v) acetic acid and N,N-dimethylacetamide (DMAc) via electrospinning. The maximum released amounts of AC depended on the $HP{\beta}CD$ content and were much greater than those released from the AC-loaded CA fiber mat. In the in vitro study, indirect cytotoxic evaluation with human dermal fibroblasts (HDFa) showed that these materials released no substances in the levels that were harmful to the cells and the cells appeared to attach and proliferate well on these substrates. However, only the CA fiber mats containing AC/$HP{\beta}CD$ complexes at the $HP{\beta}CD$ to AC molar ratio of 0.5 was effective in upregulating the production of collagen of the cultured cells.

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