Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Down-Regulation of Sox11 Is Required for Efficient Osteogenic Differentiation of Adipose-Derived Stem Cells

  • Choi, Mi Kyung (Department of Life Science, Ewha Womans University) ;
  • Seong, Ikjoo (Department of Life Science, Ewha Womans University) ;
  • Kang, Seon Ah (Department of Life Science, Ewha Womans University) ;
  • Kim, Jaesang (Department of Life Science, Ewha Womans University)
  • Received : 2014.01.29
  • Accepted : 2014.03.07
  • Published : 2014.04.30
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Abstract

Adipose-derived stem cells represent a type of mesenchymal stem cells with the attendant capacity to self-renew and differentiate into multiple cell lineages. We have performed a microarray-based gene expression profiling of osteogenic differentiation and found that the transcription factor Sox11 is down-regulated during the process. Functional assays demonstrate that down-regulation of Sox11 is required for an efficient differentiation. Furthermore, results from forced expression of constitutively-active and dominant-negative derivatives of Sox11 indicate that Sox11 functions as a transcriptional activator in inhibiting osteogenesis. Sox11 thus represents a novel regulator of osteogenesis whose expression and activity can be potentially manipulated for controlled differentiation.

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References

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