Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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ADP-Ribosylation: Activation, Recognition, and Removal

  • Li, Nan (Department of Experimental Radiation Oncology, Unit 66, The University of Texas MD Anderson Cancer Center) ;
  • Chen, Junjie (Department of Experimental Radiation Oncology, Unit 66, The University of Texas MD Anderson Cancer Center)
  • Received : 2013.08.30
  • Accepted : 2013.09.02
  • Published : 2014.01.31
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Abstract

ADP-ribosylation is a type of posttranslational modification catalyzed by members of the poly(ADP-ribose) (PAR) polymerase superfamily. ADP-ribosylation is initiated by PARPs, recognized by PAR binding proteins, and removed by PARG and other ADP-ribose hydrolases. These three groups of proteins work together to regulate the cellular and molecular response of PAR signaling, which is critical for a wide range of cellular and physiological functions.

Keywords

References

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