YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Compared Anti-inflammatory Activity of Euonymus alatus and Euonymus alatus for. ciliatodentatus (Franch. & Sav.) Hiyama Extract on Macrophages

화살나무(Euonymus alatus)와 회잎나무(Euonymus alatus for. ciliatodentatus (Franch. & Sav.) Hiyama) 추출물의 대식세포에 대한 항염증 활성비교

  • Kim, Jeong Hwa (Department of Biology Education, College of Education, Chungbuk National University) ;
  • Oh, Su-Yeon (Department of Biology Education, College of Education, Chungbuk National University) ;
  • Han, Ju Hwan (Forest Environment Research Institute) ;
  • Lee, Gooi Yong (Forest Environment Research Institute) ;
  • An, Chan Ki (Forest Environment Research Institute) ;
  • Hwang, Bang Yeon (Department of Pharmacy, Chungbuk National University) ;
  • Lee, Jae Kwon (Department of Biology Education, College of Education, Chungbuk National University)
  • 김정화 (충북대학교 사범대학 생물교육과) ;
  • 오수연 (충북대학교 사범대학 생물교육과) ;
  • 한주환 (충청북도 산림환경연구소) ;
  • 이귀용 (충청북도 산림환경연구소) ;
  • 안찬기 (충청북도 산림환경연구소) ;
  • 황방연 (충북대학교 약학대학) ;
  • 이재권 (충북대학교 사범대학 생물교육과)
  • Received : 2014.07.04
  • Accepted : 2014.11.13
  • Published : 2014.12.31
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Abstract

Euonymus alatus (EAE) and Euonymus alatus for. ciliatodentatus (Franch. & Sav.) Hiyama (EACHE) belong to the Celastraceae family and are one of the medicinal herbs used in traditional medicine as a therapeutic agent for blood circulation diseases. In this study, we prepared leaves methanolic extract of EAE (L-EAE), twigs methanolic extract of EAE (T-EAE), leaves methanolic extract of EACHE (L-EACHE) and twigs methanolic extract of EACHE (T-EACHE), and compared their anti-inflammatory activities. To analyze the anti-inflammatory activities, Raw 264.7 cells were used, since they are immature-macrophages and easily matured by lipopolysaccharide (LPS) stimulation. All extracts showed anti-inflammatory activities in the activated Raw 264.7 cells. That is, we showed that L-EACHE and T-EACHE are potent inhibitors of the production of nitric oxide and pro-inflammatory cytokines. These results are expected to serve as a guide for future studies on the ability of Celastraceae family to inhibit acute and chronic inflammatory diseases.

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