The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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A Case of Acute Tubular Necrosis and Hearing Loss Induced by Intravenous Administration of Ciprofloxacin

시프로플록사신 정맥 주사 후 발생한 급성 요세관 괴사와 청력 소실 1예

  • Kim, Jun Jae (Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine) ;
  • Kim, Hyun-Jung (Department of Pathology, Sanggye Paik Hospital, Inje University College of Medicine) ;
  • Kim, Sang Hyun (Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine) ;
  • Park, Won Do (Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine)
  • 김준재 (인제대학교 의과대학 상계백병원 내과) ;
  • 김현정 (인제대학교 의과대학 상계백병원 병리과) ;
  • 김상현 (인제대학교 의과대학 상계백병원 내과) ;
  • 박원도 (인제대학교 의과대학 상계백병원 내과)
  • Received : 2013.02.01
  • Accepted : 2013.05.23
  • Published : 2014.10.01
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Abstract

Ciprofloxacin is a broad-spectrum antibiotic used to treat a variety of infections. However, acute kidney injury is a rarely reported side effect. Ciprofloxacin-related nephrotoxicity typically manifests as acute tubulointerstitial nephritis. To the best of our knowledge, few cases of acute tubular necrosis as a complication of ciprofloxacin have been reported to date. We herein describe a case involving a 41-year-old woman treated with intravenous ciprofloxacin at 200 mg twice daily for gastroenteritis. One day after initiation of treatment, her serum creatinine level increased from 0.95 to 3.83 mg/dL and she experienced impaired hearing. Five days later, renal biopsy demonstrated acute tubular necrosis. The acute tubular necrosis encountered in this patient resolved; however, short-term hemodialysis was required. This is the first reported case of acute kidney injury associated with ciprofloxacin use in Korea.

시프로플록사신은 대표적으로 소화기 및 중추신경계 부작용이 보고되고 있다. 그러나 신독성 및 이독성은 발생 빈도가 드물어 현재까지 국내에는 보고된 바가 없다. 이에 시프로플록사신 정맥 주사 후 청력 소실과 더불어 발생한 급성 요세관 괴사 1예를 경험하였기에 국내 첫번째 사례로 보고하는 바이다.

Keywords

References

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