Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Risk of Gastric Cancer in Children with Helicobacter pylori Infection

  • Cam, Sebahat (Department of Pediatrics, Division of Pediatric Gastroenterology, Istanbul Medeniyet University Medical School)
  • Published : 2014.12.18
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Abstract

Background: Helicobacter pylori (H. pylori) is the most common chronic infectious agent in the stomach. Most importantly, it may lead to atrophy, metaplasia and cancer. The aim of this study was to investigate the incidence of H. pylori infection and to detect early mucosal changes that may lead to malignant degeneration in children. Materials and Methods: Children who underwent upper gastrointestinal endoscopy were included. Familial history of gastric cancer was noted. Endoscopic examinations were performed by a single pediatric gastroenterologist. A minimum of three biopsy samples were collected during endoscopy. The patients were accepted as H. pylori infected if results of biopsies and rapid urease test were both positive. Biopsies were evaluated for the presence and degree of chronic inflammation, the activity and severity of gastritis, glandular atrophy and intestinal metaplasia. Results: A total of 750 children (388 boys, 362 girls) were evaluated in our study, with a mean age of 10.1 years. A total of 390 patients (52%) were found to be infected with H. pylori. Among the H. pylori infected patients, 289 (74%) were diagnosed to have chronic superficial gastritis, 24 (6.2%) had gastric atrophy. Most strikingly, intestinal metaplasia was observed in 11 children, all were in the H. pylori positive group. There was no difference in the mean of age, gender and socioeconomic class between H. pylori infected and non-infected groups. The frequency of gastric cancer in family members (4 in number) was higher in patients with H. pylori infection. No gastric cancer case was reported from the parents of non-infected children. The worst biopsy parameters (atropy and metaplasia) were improved after H. pylori eradication on control endoscopy. Conclusions: The current study shows a higher prevalence of familial history of gastric cancer in H. pylori infected children. Intestinal metaplasia was also higher in the infected children. Eradication of H. pylori infection for this risk group may prevent subsequent development of gastric cancer.

Keywords

References

  1. Al-Hussaini A, Alghamdi S, Alsaaran R, et al (2014). Gastric adenocarcinoma presenting with gastric outlet obstruction in a child. Case Rep Gastrointest Med, 1-4.
  2. Alvarez MC, Ladeira MS, Scaletsky IC, et al (2013). Methylation pattern of THBS1, GATA-4, and HIC1 in pediatric and adult patients infected with Helicobacter pylori. Dig Dis Sci, 58, 2850-7. https://doi.org/10.1007/s10620-013-2742-6
  3. Axon A (2014). Helicobacter pylori and public health. Helicobacter, 19, 68-73. https://doi.org/10.1111/hel.12155
  4. Campbell DI, Warren BF, Thomas JE,et al (2001). The African enigma: low prevalence of gastric atrophy, high prevalence of chronic inflammation in West African adults and children. Helicobacter, 6, 263-67. https://doi.org/10.1046/j.1083-4389.2001.00047.x
  5. Chaturvedi R, Asim M, Piazuelo MB, et al (2014). Activation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells with DNA damage. Gastroenterology, 146, 1739-51. https://doi.org/10.1053/j.gastro.2014.02.005
  6. Correa P (1983).The gastric precancerous process. Cancer Surv, 2, 437-50.
  7. Ertem D, Harmanci H, Pehlivanoglu E (2003). Helicobacter pylori infection in Turkish preschool and school children: role of socioeconomic factors and breast feeding. Turk J Pediatr, 45, 114-22.
  8. Everhart JE (2000). Recent developments in the epidemiology of Helicobacter pylori. Gastroenterol Clin North Am, 29, 559-78. https://doi.org/10.1016/S0889-8553(05)70130-8
  9. Ford AC, Forman D, Hunt RH,et al (2014). Helicobacter pylori eradication therapy to prevent gastric cancer in healthy asymptomatic infected individuals: systematic review and meta-analysis of randomised controlled trials. BMJ, 348, 1-13.
  10. Goldthorn JF, Canizaro PC (1986). Gastrointestinal malignancies in infancy, childhood, and adolescence. Surg Clin North America, 66, 845-61.
  11. Guang W, Czinn SJ, Blanchard TG, et al (2014). Genetic regulation of MUC1 expression by Helicobacter pylori in gastric cancer cells. Biochem Biophys Res Commun, 445, 145-50. https://doi.org/10.1016/j.bbrc.2014.01.142
  12. Hardbower DM, Peek RM Jr, Wilson KT (2014). At the Bench: Helicobacter pylori, dysregulated host responses, DNA damage, and gastric cancer. J Leukoc Biol, 96, 201-12. https://doi.org/10.1189/jlb.4BT0214-099R
  13. IARC Working Group (1994). Schistosomes, liver flukes and Helicobacter pylori. IARC Working group on the evaluation of carcinogenic risks to humans. Lyon.7-14 June 1994. IARC Monogr Eval Carcinog Risks Hum, 61, 1-241.
  14. Iwanczak B, Francavailla R (2014). Helicobacter pylori infection in pediatrics. Helicobacter, 19, 46-51. https://doi.org/10.1111/hel.12158
  15. Jemal A, Bray F, Center MM et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  16. McMillan M, Mackay WG, Williams CL, et al (2011). Intrafamilial genotyping of Helicobacter pylori from faecal DNA. Gastroenterol Res Pract, 2011, 1-7.
  17. Mourad-Baars P, Hussey S, Jones NL (2010). Helicobacter pylori infection and childhood. Helicobacter, 15, 53-9.
  18. Ozturk Y, Buyukgebiz B, Arslan N et al (2003). Antral glandular atrophy and intestinal metaplasia in children with Helicobacter pylori infection. J Pediatr Gastroenterol Nutr, 37, 96-97. https://doi.org/10.1097/00005176-200307000-00020
  19. Piazuelo MB, Correa P (2013). Gastric cancer: Overview. Colomb Med, 44, 192-201.
  20. Schneider BG, Peng DF, Camargo MC, et al (2010). Promoter DNA hypermethylation in gastric biopsies from subjects at high and low risk for gastric cancer. Int J Cancer, 127, 2588-97. https://doi.org/10.1002/ijc.25274
  21. Vandenplas Y (2001). The role of Helicobacter pylori in paediatrics. Curr Opin Infect Dis, 14, 315-21. https://doi.org/10.1097/00001432-200106000-00012
  22. Vanderpas J, Bontems P, Miendje Deyi VY, et al (2014). Follow up of Helicobacter pylori infection in children over two decades (1998-2007):persistence, relapse and acquisition rates. Epidemiol Infect, 142, 767-75. https://doi.org/10.1017/S0950268813001428
  23. Yu Y, Su L, Wang X, et al (2014). Association between Helicobacter pylori infection and pathological changes in the gastric mucosa in Chinese children. Intern Med, 53, 83-8. https://doi.org/10.2169/internalmedicine.53.0918

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