Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Genetic Epidemiological Analysis of Esophageal Cancer in High-incidence Areas of China

  • Wang, Kai-Juan (Department of Epidemiology, College of Public Health, Zhengzhou University) ;
  • Yang, Jun-Xia (Department of Epidemiology, College of Public Health, Zhengzhou University) ;
  • Shi, Jia-Chen (Department of Epidemiology, College of Public Health, Zhengzhou University) ;
  • Deng, Song-Yuan (Henan Key Laboratory of Tumor Epidemiology) ;
  • Cao, Xiao-Qin (Department of Epidemiology, College of Public Health, Zhengzhou University) ;
  • Song, Chun-Hua (Department of Epidemiology, College of Public Health, Zhengzhou University) ;
  • Wang, Peng (Department of Epidemiology, College of Public Health, Zhengzhou University)
  • Published : 2014.12.18
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Abstract

Genetic epidemiological studies have shown that genetic susceptibility to esophageal cancer (EC) is an important cause of its high incidence within families in some areas of China. The purpose of this study was to obtain evidence of a genetic basis of EC in Xin-an and Xin-xiang counties in China. Familial aggregation and complex segregation analyses were performed of 79 EC families in these counties. The heritability of EC was examined using Falconer's method and complex segregation analysis was conducted with the SEGREG program in Statistical Analysis for Genetic Epidemiology (SAGE version 5.3.1). The results showed that the distribution of EC in families did not fit well into a binomial distribution. The heritability of EC among first-degree and second-degree relatives was $67.0{\pm}7.31%$ and $43.1%{\pm}9.80%$, respectively, and the summing up powered heritability was $53.2{\pm}6.74%$. The segregation ratio was 0.045. Complex segregation analysis showed that the genetic model of EC was additive. The current results provide evidence for an inherited propensity to EC in certain high-risk groups in China, and support efforts to identify the genes that confer susceptibility to this disease.

Keywords

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