Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Curcumin Inhibits the Activation of Immunoglobulin E-Mediated Mast Cells and Passive Systemic Anaphylaxis in Mice by Reducing Serum Eicosanoid and Histamine Levels

  • Li, Xian (College of Pharmacy, Yeungnam University) ;
  • Lu, Yue (School of Pharmacy, Shanghai University of Traditional Chinese Medicine) ;
  • Jin, Ye (College of Pharmacy, Yeungnam University) ;
  • Son, Jong-Keun (College of Pharmacy, Yeungnam University) ;
  • Lee, Seung Ho (College of Pharmacy, Yeungnam University) ;
  • Chang, Hyeun Wook (College of Pharmacy, Yeungnam University)
  • Received : 2013.11.01
  • Accepted : 2013.12.11
  • Published : 2014.01.31
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Abstract

Curcumin is naturally occurring polyphenolic compound found in turmeric and has many pharmacological activities. The present study was undertaken to evaluate anti-allergic inflammatory activity of curcumin, and to investigate its inhibitory mechanisms in immunoglobulin E (IgE)/Ag-induced mouse bone marrow-derived mast cells (BMMCs) and in a mouse model of IgE/Ag-mediated passive systemic anaphylaxis (PSA). Curcumin inhibited cyclooxygenase-2 (COX-2) dependent prostaglandin $D_2$ ($PGD_2$) and 5-lipoxygenase (5-LO) dependent leukotriene $C_4$ ($LTC_4$) generation dose-dependently in BMMCs. To probe the mechanism involved, we assessed the effects of curcumin on the phosphorylation of Syk and its downstream signal molecules. Curcumin inhibited intracellular $Ca^{2+}$ influx via phospholipase $C{\gamma}1$ ($PLC{\gamma}1$) activation and the phosphorylation of mitogen-activated protein kinases (MAPKs) and the nuclear factor-${\kappa}B$ (NF-${\kappa}B$) pathway. Furthermore, the oral administration of curcumin significantly attenuated IgE/Ag-induced PSA, as determined by serum $LTC_4$, $PGD_2$, and histamine levels. Taken together, this study shows that curcumin offers a basis for drug development for the treatment of allergic inflammatory diseases.

Keywords

References

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