대한의생명과학회지 (Biomedical Science Letters)

  • 제20권2호
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  • Pages.77-84
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  • 2014
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  • 1738-3226(pISSN)
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  • 2288-7415(eISSN)
대한의생명과학회 (The Korean Society for Biomedical Laboratory Sciences)
권호 표지

Secular Trends of Species and Antimicrobial Resistance of Blood Isolates in a Tertiary Medical Center for Ten Years: 2003~2012

  • Shin, Kyeong Seob (Department of Laboratory Medicine, Chungbuk National University College of Medicine) ;
  • Son, Young Il (Department of Laboratory Medicine, Chungbuk National University College of Medicine) ;
  • Kim, Yong Dae (Department of Preventive Medicine, Chungbuk National University College of Medicine) ;
  • Hong, Seung Bok (Department of Clinical Laboratory Science, Chungbuk Health & Science University) ;
  • Park, Je-Seop (Department of Biomedical Laboratory Science, College of Medical Science, Konyang University) ;
  • Kim, Sunghyun (Institute for Life Science and Biotechnology, Yonsei University) ;
  • Yu, Young-Bin (Department of Biomedical Laboratory Science, College of Medical Science, Konyang University) ;
  • Kim, Young Kwon (Department of Biomedical Laboratory Science, College of Medical Science, Konyang University)
  • 투고 : 2014.06.13
  • 심사 : 2014.06.30
  • 발행 : 2014.06.30
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초록

Periodic analysis of local epidemiologic data of prevalent pathogens of blood culture can provide clinicians with relevant information to guide empirical antibiotic therapy. In this study, we analyzed a pattern of change of causative microorganisms and antimicrobial resistance at a tertiary medical center in Chungcheong province from 2003 to 2012, retrospectively. Of 70,258 blood specimens cultured, 6,063 (8.6%) were positive. Among the positive isolates, 95.9% were aerobic or facultative anaerobic bacteria, 0.1% were anaerobes, and 3.9% were fungi. Coagulase-negative Staphylococci (CoNS) (32.9%), Escherichia coli (16.7%), Staphylococcus aureus (9.1%), Klebsiella pneumoniae (6.4%), and ${\alpha}$-hemolytic Streptococcus (5.9%) were commonly isolated bacteria, and Candida albicans (1.4%) was the most commonly isolated fungi. Enterococcus faecium progressively increased but Streptococcus pneumoniae, Acinetobacter baumannii and Proteus species gradually decreased over a period of 10 years. The multidrug-resistant microorganisms such as methicillin-resistant S. aureus (MRSA), vancomycin-resistant enterococci (VRE), cefotaxime-resistant E. coli, imipenem-resistant Pseudomonas aeruginosa (IRPA) and imipenem-resistant A. baumannii (IRAB), were significantly increased. Therefore, there is a need for a more strict control of antibiotics and a more updated guideline for the treatment of bloodstream infection.

키워드

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