Molecules and Cells

  • 제37권12호
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  • Pages.881-887
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  • 2014
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  • 1016-8478(pISSN)
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  • 0219-1032(eISSN)
한국분자세포생물학회 (Korean Society for Molecular and Cellular Biology)
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Ankyrin Repeat-Rich Membrane Spanning (ARMS)/Kidins220 Scaffold Protein Regulates Neuroblastoma Cell Proliferation through p21

  • Jung, Heekyung (Department of Oral Anatomy, School of Dentistry and Dental Research Institute, Seoul National University) ;
  • Shin, Joo-Hyun (Department of Oral Anatomy, School of Dentistry and Dental Research Institute, Seoul National University) ;
  • Park, Young-Seok (Department of Oral Anatomy, School of Dentistry and Dental Research Institute, Seoul National University) ;
  • Chang, Mi-Sook (Department of Oral Anatomy, School of Dentistry and Dental Research Institute, Seoul National University)
  • 투고 : 2014.06.30
  • 심사 : 2014.09.22
  • 발행 : 2014.12.31
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초록

Cell proliferation is tightly controlled by the cell-cycle regulatory proteins, primarily by cyclins and cyclin-dependent kinases (CDKs) in the $G_1$ phase. The ankyrin repeat-rich membrane spanning (ARMS) scaffold protein, also known as kinase D-interacting substrate of 220 kDa (Kidins 220), has been previously identified as a prominent downstream target of neurotrophin and ephrin receptors. Many studies have reported that ARMS/Kidins220 acts as a major signaling platform in organizing the signaling complex to regulate various cellular responses in the nervous and vascular systems. However, the role of ARMS/Kidins220 in cell proliferation and cell-cycle progression has never been investigated. Here we report that knockdown of ARMS/Kidins220 inhibits mouse neuroblastoma cell proliferation by inducing slowdown of cell cycle in the $G_1$ phase. This effect is mediated by the upregulation of a CDK inhibitor p21, which causes the decrease in cyclin D1 and CDK4 protein levels and subsequent reduction of pRb hyperphosphorylation. Our results suggest a new role of ARMS/Kidins220 as a signaling platform to regulate tumor cell proliferation in response to the extracellular stimuli.

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참고문헌

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피인용 문헌

  1. Stepping Out of the Shade: Control of Neuronal Activity by the Scaffold Protein Kidins220/ARMS vol.10, 2016, https://doi.org/10.3389/fncel.2016.00068
  2. Kidins220 and tumour development: Insights into a complexity of cross-talk among signalling pathways (Review) vol.40, pp.4, 2017, https://doi.org/10.3892/ijmm.2017.3093
  3. Functions of the multi-interacting protein KIDINS220/ARMS in cancer and other pathologies vol.57, pp.3, 2018, https://doi.org/10.1002/gcc.22514
  4. Kidins220/ARMS Expression Confers Proliferation But Independent of Self-Renewal in Mouse Embryonic Stem Cells vol.20, pp.6, 2014, https://doi.org/10.1089/cell.2018.0026
  5. YAP promotes the proliferation of neuroblastoma cells through decreasing the nuclear location of p27Kip1 mediated by Akt vol.53, pp.2, 2014, https://doi.org/10.1111/cpr.12734
  6. Kidins220/ARMS controls astrocyte calcium signaling and neuron-astrocyte communication vol.27, pp.5, 2020, https://doi.org/10.1038/s41418-019-0431-5