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The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Motor Neuron Disease and Stem Cell Approach for Its Remediation

  • Kim, Jong Deog (Research Center on Anti-Obesity and Health Care (RCAOHC), Chonnam National University) ;
  • Bhardwaj, Jyoti (Department of Biotechnology, Chonnam National University) ;
  • Chaudhary, Narendra (Department of Biotechnology, Chonnam National University) ;
  • Seo, Hyo Jin (Department of Biotechnology, Chonnam National University)
  • Received : 2013.05.04
  • Accepted : 2013.10.21
  • Published : 2013.10.30
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Abstract

Motor neuron disease (MND) is a fatal neurodegenerative disorder caused by progressive and selective degeneration of motor neurons (MNs). Because of the versatile nature, stem cells have the potential to repair or replace the degenerated cells. In this review, we discussed stem cell based therapies including the use of embryonic stem cells (ESCs), neural stem cells (NSCs), induced pluripotent stem cells (iPSCs) and genetically engineered cells to produce the neurotrophic factors for the treatment of MND. To achieve this goal, the knowledge of specificity of the cell target, homing and special markers are required.

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References

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