Eyelid Squamous Cell Carcinoma in a Horse in Jeju

제주도의 말에서 발생한 안검 중층편평상피 암종

  • Kim, Jae-Hoon (Gyeonggi-do Veterinary Service) ;
  • Woo, Gye-Hyeong (Department of Clinical Laboratory Science, Semyung University) ;
  • Kim, Jae-Hoon (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University)
  • 김재훈 (경기도 축산위생연구소) ;
  • 우계형 (세명대학교 임상병리학과) ;
  • 김재훈 (제주대학교 수의과대학, 수의과학연구소)
  • Accepted : 2013.09.26
  • Published : 2013.10.31

Abstract

An 8-year-old, female, mixed Thoroughbred horse was presented for the evaluation of the left upper eyelid mass with ocular discharge during 4 months. After unilateral surgery, excised eyelid mass and left eye were submitted for diagnosis. Grossly, the removed mass was $6{\times}7{\times}2$ cm in size and dome shape with rough irregular surface. On the cut surface, mass was firm and yellowish white in color. Histopathologically, severely proliferated stratified squamous epithelia were heavily invaginated into dermis, and then formed rete ridge or numerous squamous islands. These neoplastic islands were composed of multiple layers of prickle cells with intercellular bridge and central laminated keratin pearls or necrotic cellular debris. Based on the above results, this case was diagnosed as squamous cell carcinoma in upper eyelid of horse.

8세령의 암컷 잡종 더러브렛 말이 4개월간의 눈물과 함께 좌측 상안검에 종괴가 형성되어 있었다. 편측성 외과적 수술을 실시하여 좌측 안구와 안검 종괴를 절제하여 진단 의뢰되었다. 육안적으로 종괴는 $6{\times}7{\times}2$ cm 크기이고 반구형의 모양이며 표면은 불규칙하게 거칠었다. 단면상에서 종괴는 단단하고 유백색조를 띠고 있었다. 병리조직학적으로 심하게 증식된 중층편평상피세포가 진피층으로 심하게 함입되어 있었으며, 무수히 많은 표피 능선(rete ridge)과 중층편평상피 섬(squamous islands)을 형성하고 있었다. 종양세포의 섬들은 중심부에 층판상의 암진주와 괴사된 세포 붕괴물을 가지고 전형적인 세포 간교(intercellular bridge)로 연결된 여러 층의 가시세포로 구성되어있었다. 이와 같은 결과를 토대로 본 예는 말의 상안검에서 발생한 중층편평상피 암종으로 진단하였다.

Keywords

References

  1. Dubielzig RR. Tumors of the eye. In: Tumors in Domestic Animals. 4th ed. Ames: Iowa State Press. 2002: 739-744.
  2. Dugan SJ, Curtis CR, Roberts SM, Severin GA. Epidemiologic study of ocular / adnexal squamous cell carcinoma in horses. J Am Vet Med Assoc 1991; 198: 251-256.
  3. Dugan SJ, Roberts SM, Curtis CR, Severin GA. Prognostic factors and survival of horses with ocular / adnexal squamous cell carcinoma: 147 cases (1978-1988). J Am Vet Med Assoc 1991; 198: 298-303.
  4. Jung DI, Lee KW, Park KT, Wang JH, Yeon SC, Lee HJ, Lee HC. Cervical lymph node metastasis of tonsillar squamous cell carcinoma in a Shih-tzu. J Vet Clin 2011; 28: 154-158.
  5. Kafarnik C, Rawlings M, Dubielzig RR. Corneal stromal invasive squamous cell carcinoma: a retrospective morphological description in 10 horses. Vet Ophthalmol 2009; 12: 6-12. https://doi.org/10.1111/j.1463-5224.2009.00666.x
  6. Kaps S, Richter M, Philipp M, Bart M, Eule C, Spiess BM. Primary invasive ocular squamous cell carcinoma in a horse. Vet Ophthalmol 2005; 8: 193-197. https://doi.org/10.1111/j.1463-5224.2005.00358.x
  7. Kim WH, Kim BH, Park WR, Chang DW, Jeong SM, Yoon JH, Kim DY, Nam TC. Squamous cell carcinoma in an African Pigmy hedgehog. Korean J Vet Pathol 2001; 5: 1-3.
  8. Madewell BR, Theilen GH. Tumors of the skin and subcutaneous tissues. In: Veterinary Cancer Medicine. 2nd ed. Philadelphia: Lea & Febiger. 1987: 233-266.
  9. McCalla TL, Moore CP, Collier LL. Immunotherapy of periocular squamous cell carcinoma with metastasis in a pony. J Am Vet Med Assoc 1992; 200: 1678-1681.
  10. Owens DW, Knox JM, Hudson HT, Rudolph AH, Troll D. Influence of wind on chronic ultraviolet light-induced carcinogenesis. Br J Dermatol 1977; 97: 285-287. https://doi.org/10.1111/j.1365-2133.1977.tb15184.x
  11. Sandmeyer LS, Breaux CB, Grahn BH. Diagnostic ophthalmology. Can Vet J 2008; 49: 507-508.
  12. Schuh JCL. Squamous cell carcinoma of the oral, pharyngeal and nasal mucosa in the horse. Vet Pathol 1986; 23: 205-207. https://doi.org/10.1177/030098588602300217
  13. Valentine BA. Survey of equine cutaneous neoplasia in the Pacific Northwest. J Vet Diagn Invest. 2006; 18: 123-126. https://doi.org/10.1177/104063870601800121
  14. Woo GH, Seo IB, Kim JH, Kweon OK, Shin NS, Kwon SW, Kim DY. Squamous cell carcinoma in Pere David deer. Korean J Vet Pathol 1999; 3: 55-59.