Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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An Efficient Synthesis of Poly-Substituted Phenols and Pyridines from Morita-Baylis-Hillman Acetates and Diethyl Oxalacetate

  • Yu, Jin (Department of Chemistry and Institute of Basic Science, Chonnam National University) ;
  • Kim, Ko Hoon (Department of Chemistry and Institute of Basic Science, Chonnam National University) ;
  • Lee, Hyun Ju (Department of Chemistry and Institute of Basic Science, Chonnam National University) ;
  • Kim, Jae Nyoung (Department of Chemistry and Institute of Basic Science, Chonnam National University)
  • Received : 2013.06.27
  • Accepted : 2013.07.22
  • Published : 2013.10.20
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Abstract

Various phenol derivatives were synthesized in a one-pot reaction from MBH acetates and sodium diethyl oxalacetate via a [4C+2C] cyclization protocol. In addition, some pyridine derivatives could also be synthesized using the same starting materials, by isolating the $S_N2^{\prime}$ reaction intermediate and performing the cyclization with $NH_4OAc$.

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References

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