Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Multiple Primary Malignancies - A Retrospective Analysis at a Single Center in Turkey

  • Arpaci, Erkan (Department of Medical Oncology, Sakarya University, Sakarya Education and Research Hospital) ;
  • Tokluoglu, Saadet (Department of Medical Oncology, Guven Hospital) ;
  • Yetigyigit, Tarkan (Department of Medical Oncology, Namik Kemal University, Faculty of Medicine) ;
  • Alkis, Necati (Department of Medical Oncology, Ankara Oncology Training and Research Hospital)
  • Published : 2013.02.28
Download PDF
⟨ Previous Next ⟩

Abstract

Background: A literature review on 1,104,269 cancer patients concluded that the prevalence of multiple primary malignancies (MPM) is between 0.73% and 11.7%. MPMs seem to have higher incidence than that influenced by hazard only. The purpose of this study was to investigate clinically useful information for effective screening for synchronous and metachronous second primary cancers and to identify a potential surveillance protocol. Materials and Methods: Using statistical and epidemiological indicators we evaluated the patients with MPMs (double locations) admitted to Dr. Abdurrahman Yurtarslan Ankara Oncology Education and Research Hospital between 1981 and 2010. Results: Out of the 130 cases, 24 (18.4%) were synchronous while 106 cases (81.6%) were metachronous tumours. Mean interval time from first to second primary cancers was 4.65 years (0-27 years). The most frequent malignant associations were breast-breast, breast-endometrium and breast-ovary. Both primary and secondary tumors tended to be in an advanced stage explained by the low compliance of the patients to follow-up. Conclusions: The possibility that MPMs exist must always be considered during pretreatment evaluation. Screening procedures are especially useful for the early detection of associated tumors, whereas careful monitoring of patients treated for primary cancer and a good communication between patients and medical care teams should ensure early detection of secondary tumors, and subsequent appropriate management.

Keywords

References

  1. Angurana SL, Kapoor R, Kumar , et al (2010). Quadruple malignancy in a single patient: a case report and comprehensive review of literature. J Cancer Res Ther, 6, 230-2. https://doi.org/10.4103/0973-1482.65237
  2. Aydiner A, Karadeniz A, Uygun K, et al (2000). Multiple primary neoplasms at a single institution: differences between synchronous and metachronous neoplasms. Am J Clin Oncol, 23, 364-70. https://doi.org/10.1097/00000421-200008000-00011
  3. Bhatia S, Yasui Y, Robison LL, et al (2003). High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkin's disease: report from the late effects study group. J Clin Oncol, 21, 4386-94. https://doi.org/10.1200/JCO.2003.11.059
  4. Bugher JC (1934). The probability of the chance occurence of multiple malignant neoplasms. Am J Cancer, 21, 2309-824.
  5. Chaturvedi AK, Engels EA, Gilbert ES, et al (2007). Second cancers among 104,670 survivors of cervical cancer: evaluation of long term risk. J Natl Cancer Inst, 99, 1634-43. https://doi.org/10.1093/jnci/djm201
  6. Demandante CG, Troyer DA, Miles TP (2003). Multiple primary malignant neoplasms: case report and a comprehensive review of the literature. Am J Clin Oncol, 26, 79-83. https://doi.org/10.1097/00000421-200302000-00015
  7. Engeland A, Bjorge T, Haldorsen T, et al (1997). Use of multiple primary cancers to indicate associations between smoking and cancer incidence: an analysis of 500,000 cancer cases diagnosed in Norway during 1953-93. Int J Cancer, 70, 401-7. https://doi.org/10.1002/(SICI)1097-0215(19970207)70:4<401::AID-IJC5>3.0.CO;2-#
  8. Erikci AA, Ozturk A, Tekgunduz E, et al (2009). Acute myeloid leukemia complicatng multiple myeloma: a case successfully treated with etoposide, thioguanine, and cytarabine. Clin Lymphoma Myeloma, 9, 14-15.
  9. Escobar PA, Smith MT, Vasishta A, et al (2007). Leukemia-specigic chromosome damage detected by comet with florescence in situ hybridisation (comet-FISH). Mutagenesis, 22, 321-7. https://doi.org/10.1093/mutage/gem020
  10. Gulhan I, Eser S, Yakut C, et al (2009). Second primary gynecologic cancers after breast cancer in Turkish women. Int J Gynecol Cancer, 19, 648-50. https://doi.org/10.1111/IGC.0b013e3181a12e8b
  11. Horii A, Han HJ, Shimada M, et al (1994). Frequent replication errors at microsatellite loci in tumors of patients with multiple primary cancers. Cancer Res, 54, 3373-5.
  12. Hu NC, Hsieh SC, Chen TJ, et al (2009). Multiple primary malignancies including colon, stomach, lung, breast, and liver cancer: a case report and literature review. Chin Med J (Eng), 122, 3091-3.
  13. Kaneko S, Yamaguchi N (1999). Epidemiological analysis of site relationships of sychronous and metachronous multiple primary cancers in the National Cancer Center, Japan, 1962-1996. Jpn J Clin Oncol, 29, 96-105 https://doi.org/10.1093/jjco/29.2.96
  14. Merrouche Y, Mugneret F, Cahn JY (2006). Secondary acute promyelocytic leukemia following irinotecan and oxaliplatin for advanced colon cancer. Ann Oncol, 17, 1025-6. https://doi.org/10.1093/annonc/mdj082
  15. Morgenfeld EL, Tognelli F, Gil Deza E, et al (2003). Synchronous end metachronous second (ST) end third (TT) primary tumors in a large patient population. Proc ASCO, 22, 3152
  16. Mussari S, Amichetti M, Tomio L (2000). Quadruple cancer in a single patient: a report of four cases. Eur J Surg Oncol, 26, 614-6 https://doi.org/10.1053/ejso.2000.0958
  17. Noronha V, Berliner N, Ballen KK, et al (2006). Treatment related myelodisplasia/AML ina patient with a history of breast cancer and an oligodendroglioma treated with temozolomide: case study and review of the literature. Neuro Oncol, 8, 280-3. https://doi.org/10.1215/15228517-2006-003
  18. Passman MA, Pommier RF, Vetto JT (1996). Synchronous colon primaries have the same prognosis as solitary colon cancers. Dies Colon Rectum, 39, 329-34. https://doi.org/10.1007/BF02049477
  19. Slaughter DP, Southwick HW, Smejkal W (1953). Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origins. Cancer, 6, 963-8 https://doi.org/10.1002/1097-0142(195309)6:5<963::AID-CNCR2820060515>3.0.CO;2-Q
  20. Suzuki T, Takahashi H, Yao K, et al (2002). Multiple primary malignancies in the head and neck: a clinical review of 121 patients. Acta Otolaryngol, 547, 88-92
  21. Tamura M, Shinagawa M, Funaki Y (2003). Synchronous triple early cancers occuring in the stomach, colon and gallbladder. Asian J Surg, 26, 46-8. https://doi.org/10.1016/S1015-9584(09)60216-5
  22. Thompson WD (1986). Methodologic perspectives on the study of multiple primary cancers. Yale J Biol Med, 59, 505-16.
  23. Van Dalen R, Churh J, McGannon E, et al (2003). Patterns of surgery in patients belonging to Amsterdam-positive families. Dis Colo Rectum, 46, 617-20. https://doi.org/10.1007/s10350-004-6619-9
  24. Vaslamatzis M, Alevizopoulos N, Petraki C, et al (2003). Second primary neoplasms (SPN) in cancer patients. Proc ASCO, 22, 3581
  25. Vogel VG (2006). Identifying and screening patients at risk of second cancers. Cancer Epidemiol Biomarkers Prev, 15, 2027-32 https://doi.org/10.1158/1055-9965.EPI-06-0416
  26. Woodward WA, Strom EA, McNeese MD, et al (2003). Cardiovascular death and second non-breast cancer malignancy after postmastectomy radiation and doxorubicin-based chemotherapy. Int J Radiat Oncol Biol Phys, 57, 327-35 https://doi.org/10.1016/S0360-3016(03)00594-7
  27. Yamamoto S, Yoshimura K, Ri S, et al (2006). The risk of multiple primary malignancies with colorectal carcinoma. Dis Colon Rectum, 49, 30-6. https://doi.org/10.1007/s10350-006-0600-8

Cited by

  1. Influence of Residential Environment and Lifestyle on Multiple Primary Malignancies in Taiwan vol.16, pp.8, 2015, https://doi.org/10.7314/APJCP.2015.16.8.3533