Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Evaluation of Shelf-life of Bojungikgi-tang by Long-term Storage Test

장기보존시험에 따른 보중익기탕 전탕팩의 유통기한 평가

  • Seo, Chang-Seob (Herbal Medicine Formulation Research Group, Korea Institute of Oriental Medicine) ;
  • Kim, Jung-Hoon (Herbal Medicine Formulation Research Group, Korea Institute of Oriental Medicine) ;
  • Kim, Seong-Sil (Herbal Medicine Formulation Research Group, Korea Institute of Oriental Medicine) ;
  • Lim, Soon-Hee (The Institute of Life Science Research, Global Health Care Co. Ltd.) ;
  • Shin, Hyeun-Kyoo (Herbal Medicine Formulation Research Group, Korea Institute of Oriental Medicine)
  • 서창섭 (한국한의학연구원 한약방제연구그룹) ;
  • 김정훈 (한국한의학연구원 한약방제연구그룹) ;
  • 김성실 (한국한의학연구원 한약방제연구그룹) ;
  • 임순희 ((주)글로벌헬스케어 생명과학연구소) ;
  • 신현규 (한국한의학연구원 한약방제연구그룹)
  • Received : 2013.04.23
  • Accepted : 2013.05.22
  • Published : 2013.06.30
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Abstract

The aim of this study was to evaluate the shelf-life of Bojungikgi-tang (Buzhongyiqi-tang in Chinese) by long-term storage test. Experiments were performed to evaluate the stability such as the selected physicochemical, pH, identification, heavy metal, microbiological experiment, and amount of marker compounds under a long-term storage test of Bojungikgi-tang decoction. The significant change was not showed in pH, heavy metal, microbiological, and identification test based on long-term storage test. Furthermore, the HPLC analysis was performed for the determinations of liquiritin, glycyrrhizin, nodakenin, and hesperidin in Bojungikgi-tang by long-term storage test. We were calculated shelf-life of Bojungikgi-tang decoction based on the amount change of four constituents. Consequently, Shelf-life by four compounds at room temperature was predicted 23 month. The suggested shelf-life would be helpful on the storage and distribution of herbal medicine.

Keywords

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