Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Antimicrobial Activities and Free Radical Scavenging Effect of Korean Folk Plants

민속식물의 항균활성 및 산화적 스트레스 개선 효과

  • Choi, Jung Ran (Department of Food Science and Nutrition, Pusan National University) ;
  • Lee, Dong Gu (Department of Integrative Plant Science, Chung-Ang University) ;
  • Ku, Jajung (Department of Forest Resource Conservation, Korea National Arboretum) ;
  • Lee, Sang Yong (Department of Forest Resource Conservation, Korea National Arboretum) ;
  • Kim, Hyun Ji (Department of Forest Resource Conservation, Korea National Arboretum) ;
  • Park, Kwang-Woo (Department of Forest Resource Conservation, Korea National Arboretum) ;
  • Cho, Eun Ju (Department of Food Science and Nutrition, Pusan National University) ;
  • Lee, Sanghyun (Department of Integrative Plant Science, Chung-Ang University)
  • 최정란 (부산대학교 식품영양학과) ;
  • 이동구 (중앙대학교 식물시스템과학과) ;
  • 구자정 (국립수목원 자원보존과) ;
  • 이상용 (국립수목원 자원보존과) ;
  • 김현지 (국립수목원 자원보존과) ;
  • 박광우 (국립수목원 자원보존과) ;
  • 조은주 (부산대학교 식품영양학과) ;
  • 이상현 (중앙대학교 식물시스템과학과)
  • Received : 2013.05.16
  • Accepted : 2013.06.10
  • Published : 2013.06.30
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Abstract

We investigated the antioxidative and antimicrobial activities of the methanol extracts from Korean folk plants (MKs) in Chungcheong Province. Among 30 MKs, 16 plants at $100{\mu}g/ml$ showed over 90% scavenging activity of 1,1-diphenyl-2-picrylhydrazy (DPPH) and 30 plants exerted the hydroxyl radical scavenging effect over 55%. Fourteen plants at the concentration $50{\mu}g/30{\mu}l$ showed strong microbial inhibition activity against Escherichia coli and Staphylococcus aureus, with clear zone greater than 11 mm in disc assays. Furthermore, the protective effect against anti-inflammatory system using RAW 264.7 macrophage cell was also studied. The treatment of LPS & INF-${\gamma}$ to RAW 264.7 cell induced nitric oxide (NO), however inhibit the formation of NO less than 50% of 5 plants. The present result indicates that the 30 species of MKs exerts protective effect of oxidative stress, antimicrobial activities and anti-inflammatory. In particular, Rhus javanica and Cornus controversa showed stronger effect on not only radical scavenging activity and inhibits growth of S. aureus but also highest protective effects from inflammation.

Keywords

References

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