Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Ceramium boydenii, a Red Alga, Inhibits MDC/CCL22 Production Via Suppression of STAT1 Activation in HaCaT Keratinocyte

HaCaT 각질형성세포에서 홍조류인 단박(Ceramium boydenii)의 STAT1 활성 억제를 통한 MDC/CCL22 생성 억제 효과

  • Kang, Na-Jin (Department of Biomedicine & Drug Development, Jeju National University) ;
  • Kang, Gyeung-Jin (Department of Medicine, Jeju National University School of Medicine) ;
  • Han, Sang-Chul (Department of Medicine, Jeju National University School of Medicine) ;
  • Hyun, Eun-A (Department of Medicine, Jeju National University School of Medicine) ;
  • Koo, Dong-Hwan (Department of Biomedicine & Drug Development, Jeju National University) ;
  • Koh, Young-Sang (Department of Biomedicine & Drug Development, Jeju National University) ;
  • Ko, Mi-Hee (Jeju Biodiversity Research Institute, Jeju Technopark) ;
  • Hyun, Jin Won (Department of Biomedicine & Drug Development, Jeju National University) ;
  • Kang, Hee-Kyoung (Department of Biomedicine & Drug Development, Jeju National University) ;
  • Yoo, Eun-Sook (Department of Biomedicine & Drug Development, Jeju National University)
  • 강나진 (제주대학교 일반대학원 의생명.신약개발학과) ;
  • 강경진 (제주대학교 의학전문대학원 의학과) ;
  • 한상철 (제주대학교 의학전문대학원 의학과) ;
  • 현은아 (제주대학교 의학전문대학원 의학과) ;
  • 구동환 (제주대학교 일반대학원 의생명.신약개발학과) ;
  • 고영상 (제주대학교 일반대학원 의생명.신약개발학과) ;
  • 고미희 (제주 생물종다양성 연구소) ;
  • 현진원 (제주대학교 일반대학원 의생명.신약개발학과) ;
  • 강희경 (제주대학교 일반대학원 의생명.신약개발학과) ;
  • 유은숙 (제주대학교 일반대학원 의생명.신약개발학과)
  • Received : 2013.03.27
  • Accepted : 2013.06.10
  • Published : 2013.06.30
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Abstract

Ceramium boydenii belongs to euphorbia humitusa of red algae, and is distributed along the coast of Jeju island. This study was conducted to examine the anti-inflammatory effect and action mechanism of C. boydenii in the human keratinocyte cell line HaCaT. The 80% EtOH extract of C. boydenii inhibits the production of MDC (macrophage derived chemokine), an inflammatory chemokine, induced by IFN-${\gamma}$ and TNF-${\alpha}$ in a concentration dependent manner. It also suppressed the phosphorylation and nuclear translocation of STAT1, a key transcription factor in IFN-${\gamma}$ and TNF-${\alpha}$ signaling pathway, at the effective concentrations. These results suggest that C. boydenii demonstrates the anti-inflammatory activity via the suppression of STAT1 activation and has the significant value as an anti-inflammatory source.

Keywords

References

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