Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Danshensu Isolated from Prunella vulgaris var. Lilacina Attenuates MK-801-induced Prepulse Inhibition Deficits in Mice

하고초 추출물로부터 분리된 Danshensu의 MK-801으로 유도된 사전자극 억제 손상의 회복에 대한 작용

  • Hong, Sung In (Department of East-West Integrated Medicine, Kyung Hee University Medical Center) ;
  • Park, Se Jin (Department of Life and Nanopharmaceutical Sciences, Kyung Hee University) ;
  • Lew, Jae Hwan (Department of East-West Integrated Medicine, Kyung Hee University Medical Center) ;
  • Ryu, Jong Hoon (Department of Life and Nanopharmaceutical Sciences, Kyung Hee University)
  • 홍성인 (경희의료원 동서협진실) ;
  • 박세진 (경희대학교 나노의약생명과학과) ;
  • 류재환 (경희의료원 동서협진실) ;
  • 류종훈 (경희대학교 나노의약생명과학과)
  • Received : 2013.04.25
  • Accepted : 2013.05.29
  • Published : 2013.06.30
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Abstract

Schizophrenia is a severe psychiatric disorder and characterized by positive symptom (i.e., delusions, hallucinations), negative symptom (i.e., lack of emotion, social withdrawal), and cognitive impairment. Previously, we reported that the ethanolic extract of Prunella vulgaris var. lilacina attenuated the MK-801-induced schizophrenia-like behaviors such as prepulse inhibition (PPI) deficits and cognitive impairment in mice. The aim of the present study was to investigate whether danshensu isolated from P. vulgaris var. lilacina attenuates MK-801-induced sensorimotor gating dysfunction (PPI deficits), hyperlocomotion, and memory impairment in mice. Acute administration of danshensu (1, 3, or 10 mg/kg) significantly ameliorated the MK-801-induced PPI deficits in the acoustic startle response test. We also observed that the impaired recognition memory induced by MK-801 was attenuated by danshensu (1 mg/kg) in the novel object recognition test. However, danshensu failed to reverse the MK-801-induced hyperlocomotion in the open-field test. Collectively, the present results indicate danshensu would be an active agent for treating neuropsychiatric disorders such as schizophrenia.

Keywords

References

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