대한한의학방제학회지 (Herbal Formula Science)

  • 제21권1호
  • /
  • Pages.131-141
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  • 2013
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  • 1229-1218(pISSN)
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  • 2288-5641(eISSN)
대한한의학방제학회 (The Korean Medicine Society for the Herbal Formula Study)
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가감공진단(加減拱辰丹) (WSY-1075)의 접촉성 피부염 유발 모델동물에 대한 개선효과

The Ameliorative Effects of Gagam-GongJin-dan (WSY-1075) in Contact Dermatitis-induced Animal Model

  • 황성연 (우석대학교 한의과대학 방제학교실) ;
  • 이가위 (우석대학교 한의과대학 방제학교실) ;
  • 이승호 (우석대학교 한의과대학 방제학교실) ;
  • 김홍준 (우석대학교 한의과대학 방제학교실)
  • Hwang, Sung Yeoun (Department of Korean Medical Prescription, Woosuk University) ;
  • Lee, Chia Wei (Department of Korean Medical Prescription, Woosuk University) ;
  • Lee, Seung Ho (Department of Korean Medical Prescription, Woosuk University) ;
  • Kim, Hong Jun (Department of Korean Medical Prescription, Woosuk University)
  • 투고 : 2013.05.30
  • 심사 : 2013.06.12
  • 발행 : 2013.06.30
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초록

Objectives : This study was performed to assess the ameliorative effects of Gagam-GongJin-dan (WSY-1075) composited with Corni Fructus, Angelica gigantis Radix, Lycii Fructus, Ginseng Radix, Cervi parvum Cornu and Cinnamomi Cortex in contact dermatitis animal model. Methods : WSY-1075 was orally administrated the various concentrations (50-400 mg/kg, body weight/day) with one time per day for 10 days from 4 days after DNFB sensitization. We investigated ameliorative effects of WST-1075 on the scratching behavior, skin clinical serverity and inflammatory mediators in 2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis mice. Results : The orally administration of WSY-1075 (400 mg/kg) inhibited the scratching behavior induced by sensitization and challenge with DNFB. WSY-1075 (200 mg/kg or 400 mg/kg) administration also reduced the skin damage, inflammatory mediators, mast cell infiltration induced by DNFB. Moreover, WSY-1075 (above 200 mg/kg) administration inhibited the serum levels of IgE and IL-4 in DNFB-induced contact dermatitis mice. Conclusions : These results suggest that WSY-1075 administration (200 mg/kg or 400 mg/kg) has the ameliorative effects on the scratching behavior, the clinical signs, mast cell infiltration and inflammatory mediators in DNFB-induced contact dermatitis animal model mice.

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피인용 문헌

  1. Effects of Hyeongbangpaedok-san (HBPDS) on Allergic Contact Dermatitis (ACD) induced by DNFB in Mice vol.26, pp.2, 2014, https://doi.org/10.7730/JSCM.2014.26.2.180
  2. A Study on Roman Nomenclature of Prescriptions in Herbal Formula Science vol.21, pp.2, 2013, https://doi.org/10.14374/HFS.2013.21.2.013