대한한의학방제학회지 (Herbal Formula Science)

  • 제21권1호
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  • Pages.119-130
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  • 2013
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  • 1229-1218(pISSN)
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  • 2288-5641(eISSN)
대한한의학방제학회 (The Korean Medicine Society for the Herbal Formula Study)
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도인승기탕에 의한 당뇨병성 혈관장애 개선효과

Therapeutic Effect of Doinseunggi-tang on Diabetic Vascular Dysfunction

  • 이윤정 (한의과대학 생리학교실, 원광대학교 한의학전문대학원, 한방체액조절연구센터) ;
  • 김언국 (원광대학교 한의학전문대학원) ;
  • 김혜윰 (한의과대학 생리학교실, 원광대학교 한의학전문대학원, 한방체액조절연구센터) ;
  • 윤정주 (한의과대학 생리학교실, 원광대학교 한의학전문대학원, 한방체액조절연구센터) ;
  • 이소민 (한의과대학 생리학교실, 원광대학교 한의학전문대학원, 한방체액조절연구센터) ;
  • 이용표 (한의과대학 생리학교실, 원광대학교 한의학전문대학원, 한방체액조절연구센터) ;
  • 이건목 (원광대학교 한의학전문대학원) ;
  • 강대길 (한의과대학 생리학교실, 원광대학교 한의학전문대학원, 한방체액조절연구센터) ;
  • 이호섭 (한의과대학 생리학교실, 원광대학교 한의학전문대학원, 한방체액조절연구센터)
  • Lee, Yun Jung (College of Oriental Medicine, Professional Graduate School of Oriental Medicine, Hanbang Body-fluid research center, Wonkwang University) ;
  • Kim, Eon Kuk (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kim, Hye Yoom (College of Oriental Medicine, Professional Graduate School of Oriental Medicine, Hanbang Body-fluid research center, Wonkwang University) ;
  • Yoon, Jung Joo (College of Oriental Medicine, Professional Graduate School of Oriental Medicine, Hanbang Body-fluid research center, Wonkwang University) ;
  • Lee, So Min (College of Oriental Medicine, Professional Graduate School of Oriental Medicine, Hanbang Body-fluid research center, Wonkwang University) ;
  • Lee, Yong-Pyo (College of Oriental Medicine, Professional Graduate School of Oriental Medicine, Hanbang Body-fluid research center, Wonkwang University) ;
  • Lee, Geon Mok (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kang, Dae Gill (College of Oriental Medicine, Professional Graduate School of Oriental Medicine, Hanbang Body-fluid research center, Wonkwang University) ;
  • Lee, Ho Sub (College of Oriental Medicine, Professional Graduate School of Oriental Medicine, Hanbang Body-fluid research center, Wonkwang University)
  • 투고 : 2013.03.28
  • 심사 : 2013.04.19
  • 발행 : 2013.06.30
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초록

Objectives : Diabetes mellitus is the leading cause for vascular complications such as atherosclerosis. The present study is to investigate whether Doinseunggi-tang (DST) improves diabetic vascular dysfunction in type II diabetes. Methods : The db/db mice were treated with high fat/high cholesterol diet and DST (200 mg/kg/day) for 8 weeks. Results : DST significantly lowered blood glucose and systolic blood pressure. In addition, DST also markedly decreased total plasma cholesterol, triglyceride, and LDL-cholesterol, whereas increased the HDL-cholesterol. Vascular relaxation of aortic rings by acetylcholine or SNP was ameliorated by DST in a dose-dependent manner. Damage of vascular intima and hypertrophic of media was improved by DST. Immunohistological study revealed that DST attenuated the increase of ICAM-1, VCAM-1, and ET-1 expression in thoracic aorta. Conclusions : Taken together, DST suppressed hyperglycemia and diabetic vascular dysfunction in type II db/db mice. The present data suggests that Doinseunggi-tang may be prevent a development of diabetic atherosclerosis.

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피인용 문헌

  1. A Study on Roman Nomenclature of Prescriptions in Herbal Formula Science vol.21, pp.2, 2013, https://doi.org/10.14374/HFS.2013.21.2.013
  2. The Korean herbal medicine, Do In Seung Gi-Tang, attenuates atherosclerosis via AMPK in high-fat diet-induced ApoE−/− mice vol.16, pp.1, 2016, https://doi.org/10.1186/s12906-016-1309-4
  3. Dohaekseunggi-tang extract inhibits obesity, hyperlipidemia, and hypertension in high-fat diet-induced obese mice vol.14, pp.1, 2014, https://doi.org/10.1186/1472-6882-14-372