대한한의학방제학회지 (Herbal Formula Science)

  • 제21권1호
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  • Pages.91-98
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  • 2013
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  • 1229-1218(pISSN)
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  • 2288-5641(eISSN)
대한한의학방제학회 (The Korean Medicine Society for the Herbal Formula Study)
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당귀와 구기자 에탄올 추출물의 피부 미백작용

Skin Whitening Effects of Extracts from Angelicae Gigantis Radix and Lycii fructus Ethanol Extracts

  • 황성연 (우석대학교 한의과대학 방제학교실) ;
  • 이정탁 (우석대학교 한의과대학 방제학교실) ;
  • 김영욱 (우석대학교 한의과대학 방제학교실) ;
  • 김홍준 (우석대학교 한의과대학 방제학교실)
  • Hwang, Sung Yeoun (Department of Korean Medical Prescription, Woosuk University) ;
  • Lee, Jeong Tak (Department of Korean Medical Prescription, Woosuk University) ;
  • Kim, Yeong Uk (Department of Korean Medical Prescription, Woosuk University) ;
  • Kim, Hong Jun (Department of Korean Medical Prescription, Woosuk University)
  • 투고 : 2013.05.30
  • 심사 : 2013.06.11
  • 발행 : 2013.06.30
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초록

Objective : The purpose of this study was to investigate the synergistic effect of Angelicae gigantis Radix (AG) and Lycii fructus (LF) ethanol extracts on skin-whitening effects. Method : LFAG extracts were prepared by extracting with 80% ethanol. The efficacy of LFAG was judged by measurement of cell viability, tyrosinase activity, melanin production, tyrosinase and microphthalmia-associated transcription factor (MITF) expression in B16F10 murine melanoma cells by lipopolysaccharides (LPS) treatment. Results : Each extract (LF or AG) inhibited the tyrosinase activity in a dose-dependent manner. The co-treatment of LFAG extracts ($25{\mu}g/mL$ LF plus $25{\mu}g/mL$ AG) markedly suppressed the LPS-induced cellular tyrosine activity, melanin production, tyrosinase and MMP-1 expression in B16F10 murine melanoma cells. These suppressive effects were synergistically increased by their combination. Conclusions : With these observations, we suggest that the extracts from Lycii fructus and Angelica gigantis Radix could be potent natural materials for whitening skin.

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참고문헌

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피인용 문헌

  1. Separation and Characteristics of ADH and ALDH Activators in Fermented Lycii fructus Extract vol.31, pp.2, 2016, https://doi.org/10.7841/ksbbj.2016.31.2.134
  2. An Experimental Study on the Effect of Angelica acutiloba Ethanol Extract on Hyaluronic Acid Synthesis vol.28, pp.1, 2015, https://doi.org/10.6114/jkood.2015.28.1.032
  3. A Clinical Study for Moisturizing Effects of Herbal Cosmetics Containing Sinhyotakrisan Extracts vol.29, pp.1, 2016, https://doi.org/10.6114/jkood.2016.29.1.081
  4. Comparison of Anti-Skin Wrinkle Activities of Aronia melanocarpa Extracts by Extraction Methods vol.22, pp.3, 2014, https://doi.org/10.7783/KJMCS.2014.22.3.217