대한한의학방제학회지 (Herbal Formula Science)

  • 제21권1호
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  • Pages.80-90
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  • 2013
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  • 1229-1218(pISSN)
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  • 2288-5641(eISSN)
대한한의학방제학회 (The Korean Medicine Society for the Herbal Formula Study)
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황련해독탕(黃連解毒湯)의 아토피 피부염 개선 효과(效果)

Ameliorative Effects of Hwangnyeonhaedok-tang on Atopic Dermatitis

  • 기호필 (원광대학교 한의과대학 방제학교실) ;
  • 장선일 (전주대학교 보건관리학과) ;
  • 윤용갑 (원광대학교 한의과대학 방제학교실)
  • 투고 : 2013.05.24
  • 심사 : 2013.06.10
  • 발행 : 2013.06.30
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초록

Objectives : The water extract of Hwangnyeonhaedok-tang (HHT), composed of the Scutellariae Radix, Coptidis Rhizoma, Phellodendri Cortex and Gardeniae Fructus has been traditionally used to treat fever, inflammation, gastritis and hypertension in east asia. However, little is known about the ameliorative effects of HHT on atopic dermatitis. Therefore, the purpose of this study was to investigate the therapeutic effect of HHT on atopic dermatitis Methods : We investigated the inhibitory effects of HHT on the production of proinflammatory cytokines in rat peritoneal mast cells (RPMCs), on the scratching behavior in ICR mice, and on atopic dermatitis symptoms in 2,4-dinitrofluorobenzene (DNFB)-induced atopic dermatitis-like model hairless mice. Results : Levels of TNF-${\alpha}$ and IL-$1{\beta}$ increased by PMA plus A23187 co-treatment were significantly inhibited by HHT in a dose-dependent manner. HHT also inhibited the histamine release from RPMCs stimulated by compound 48/80, which promotes histamine release. The oral administration of HHT reduced the scratching behavior induced by compound 48/80 and histamine in ICR mice. Furthermore, the intradermal treatment of HHT reduced the ear edema, skin lesions, and atopic molecular marker (IgE and IL-4) in DNFB-induced atopic dermatitis model mice. Conclusions : These results suggest that HHT may be used as a potential treatment for AD as a prescription for treatment of atopic dermatitis.

키워드

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피인용 문헌

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  2. The Effect of the Polygonum tinctoria Niram on Atopic Dermatitis in DNCB-Induced Hairless Mice vol.22, pp.1, 2014, https://doi.org/10.14374/HFS.2014.22.1.141
  3. Effects of Ato-tang on DNCB-induced atopic dermatitis in Mice vol.31, pp.4, 2016, https://doi.org/10.6116/kjh.2016.31.4.79.
  4. The Effect of the Polygonum tinctoria Niram on Atopic Dermatitis in Dinitrochlorobenzene-Induced BALB/c Mice vol.44, pp.2, 2014, https://doi.org/10.9729/AM.2014.44.2.53
  5. Two Case Report of Obesity with atopic dermatitis Treated with Hwangryunhaedoktang-gamibang vol.39, pp.3, 2018, https://doi.org/10.13048/jkm.18027