YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Quantitative Analysis for the Quality Evaluation of Sinomenine, Magnoflorine and Syringaresinol in Sinomenium acutum

방기의 품질 평가를 위한 Sinomenine, Magnoflorine, Syringaresinol의 함량 분석

  • Lee, Jiwoo (Department of Medical Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University) ;
  • Weon, Jin Bae (Department of Medical Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University) ;
  • Yun, Bo-Ra (Department of Medical Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University) ;
  • Eom, Min Rye (Department of Medical Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University) ;
  • Ma, Choong Je (Department of Medical Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University)
  • 이지우 (강원대학교 생물의소재공학전공) ;
  • 원진배 (강원대학교 생물의소재공학전공) ;
  • 윤보라 (강원대학교 생물의소재공학전공) ;
  • 엄민례 (강원대학교 생물의소재공학전공) ;
  • 마충제 (강원대학교 생물의소재공학전공)
  • Received : 2013.04.29
  • Accepted : 2013.06.24
  • Published : 2013.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Sinomenium acutum has been used for the treatment of rheumatoid arthritis, arrhythmia, and pain. We evaluated the quality of S. acutum extract by quantitatively analyzing its components such as sinomenine, magnoflorine and syringaresinol with the simultaneous determination method using HPLC-DAD. A total of 53 samples collected from different localities were evaluated with this quality evaluation method. Sinomenine, magnoflorine and syringaresinol from tested samples ranged from 0.0649~9.1050%, 0.7460~10.7590% and 0.0010~0.2441%, respectively. In the current study, we were able to exhibit the diverse quality of S. acutum samples collected from various locations using the simultaneous determination method.

Keywords

References

  1. 손영종, 이영종 : 청풍등과 복령이 혈당량이 미치는 영향. 대한본초학회지 18, 65 (2003).
  2. 기성식, 이영종 : 방기황기탕 및 방기복령탕이 고지혈증 흰쥐에 미치는 효과. 대한본초학회지 20, 149 (2005).
  3. 김태한, 김영일, 홍권의, 임윤경, 이현, 이병렬 : 백서의 족삼리에 시술한 청풍등약침이 항암 및 면역증강에 미치는 영향. 대한경락경혈학회지 21, 79 (2004).
  4. 이현 : 백서의 중완에 시술한 청풍등약침이 항암 및 면역기능에 미치는 영향. 대한침구의학회지 21, 85 (2004).
  5. Kim, H. M., Moon, P. D., Chae, H. J., Kim, H. R., Chung, J. G., Kim, J. J. and Lee, E. J. : The stem of Sinomenium acutum inhibits mast cell-mediated anaphylactic reactions and tumor necrosis factor-$\alpha$ production from rat peritoneal mast cells. J. Ethnopharmacol. 70, 135 (2000).
  6. Liu, L., Buchner, E., Beitze, D., Schmidt-weber, C. B., Kaever, V., Emmrich, F. and Kinne, R. W. : Amelioration of rat experimental arthritides by treatment with the alkaloid sinomenine. Int. J. Immunopharmac. 18, 529 (1996).
  7. Zhao, Z. Z., Liang, Z. T., Zhou, H., Jiang, Z. H., Liu, Z. Q., Wong, Y. F., Xu, H. X. and Liu, L. : Quantification of sinomenine in Caulis Sinomenii collected from different growing regions and wholesale herbal markets by a modified HPLC method. Biol. Pharm. Bull. 28, 105 (2005). https://doi.org/10.1248/bpb.28.105
  8. Wang, Q. and Li, X. K. : Immunosuppressive and antiinflammatory activities of sinomenine. Int. Immunopharmacol. 11, 373 (2011). https://doi.org/10.1016/j.intimp.2010.11.018
  9. Liu, L., Resch, K. and Kaever, V. : Inhibition of lymphocyte proliferation by the anti-arthritic drug sinomenine. Int. J. Immunopharmac. 16, 685 (1994). https://doi.org/10.1016/0192-0561(94)90142-2
  10. Vieregge, B., Resch, K. and Kaever, V. : Synergistic effects of the alkaloid sinomenine in combination with the immunosuppressive drugs tacrolimus and mycophenolic acid. Planta Med. 65, 80 (1999). https://doi.org/10.1055/s-2006-960446
  11. Hung, T. M., Lee, J. P., Min, B. S., Choi, J. S., Na, M. K., Zhang, X. F., Ngoc, T. M., Lee, I. S. and Bae, K. H. : Magnoflorine from Coptidis Rhizoma protects high density lipoprotein during oxidant stress. Biol. Pharm. Bull. 30, 1157 (2007). https://doi.org/10.1248/bpb.30.1157
  12. Park, B. Y., Oh, S. R., Ahn, K. S., Kwon, O. K. and Lee, H. K. : Syringaresinol inhibits proliferation of human promyelocytic HL-60 leukemia cells via G1 arrest and apoptosis. Int. Immunopharmacol. 8, 967 (2008). https://doi.org/10.1016/j.intimp.2008.02.012
  13. Miyazawa, M., Utsunomiya, H., Inada, K., Yamada, T., Okuno, Y., Tanaka, H. and Tatematsu, M. : Inhibition of Helicobacter pylori motility by (+)-Syringaresinol from unripe Japanese apricot. Biol. Pharm. Bull. 29, 172 (2006). https://doi.org/10.1248/bpb.29.172
  14. Korea Food and Drug Administration : Guidelines for the establishment of concentration limit for crude drugs. Seoul (2007).
  15. Sim, H. J., Kim, J. H., Lee, K. R. and Hong, J. : Simultaneous determination of structurally diverse compounds in different Fangchi species by UHPLC-DAD and UHPLC-ESI-MS/MS. Molecules. 18. 5235 (2013). https://doi.org/10.3390/molecules18055235