Journal of Periodontal and Implant Science

  • 제43권1호
  • /
  • Pages.3-11
  • /
  • 2013
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  • 2093-2278(pISSN)
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  • 2093-2286(eISSN)
대한치주과학회 (Korean Academy of Periodontology)
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Innate immune response to oral bacteria and the immune evasive characteristics of periodontal pathogens

  • Ji, Suk (Department of Periodontology, Korea University Anam Hospital) ;
  • Choi, Youngnim (Department of Oral Microbiology and Immunology, Dental Research Institute, Seoul National University School of Dentistry)
  • 투고 : 2012.12.24
  • 심사 : 2013.01.18
  • 발행 : 2013.02.28
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초록

Periodontitis is a chronic inflammation of periodontal tissue caused by subgingival plaque-associated bacteria. Periodontitis has long been understood to be the result of an excessive host response to plaque bacteria. In addition, periodontal pathogens have been regarded as the causative agents that induce a hyperinflammatory response from the host. In this brief review, host-microbe interaction of nonperiodontopathic versus periodontopathic bacteria with innate immune components encountered in the gingival sulcus will be described. In particular, we will describe the susceptibility of these microbes to antimicrobial peptides (AMPs) and phagocytosis by neutrophils, the induction of tissue-destructive mediators from neutrophils, the induction of AMPs and interleukin (IL)-8 from gingival epithelial cells, and the pattern recognition receptors that mediate the regulation of AMPs and IL-8 in gingival epithelial cells. This review indicates that true periodontal pathogens are poor activators/suppressors of a host immune response, and they evade host defense mechanisms.

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과제정보

연구 과제 주관 기관 : National Research Foundation of Korea

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