The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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The Effects of Platycodi Radix on Obese Type 2 Diabetes Mouse Model Induced by High Fat, High Carbohydrate Diet

길경 투여가 고지방, 고탄수화물 식이로 유발된 비만형 제2형 당뇨병 동물모델에 미치는 영향

  • Kwon, Oh-Jun (Dept. of Internal medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Seung-Wook (Dept. of Internal medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Paik, Sun-Ho (Dept. of Internal medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Han, Su-Ryun (Dept. of Internal medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Ahn, Young-Min (Dept. of Internal medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Ahn, Se-Young (Dept. of Internal medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Byung-Cheol (Dept. of Internal medicine, College of Oriental Medicine, Kyung Hee University)
  • 권오준 (경희대학교 한의과대학 신계내과학교실그룹) ;
  • 이승욱 (경희대학교 한의과대학 신계내과학교실그룹) ;
  • 백선호 (경희대학교 한의과대학 신계내과학교실그룹) ;
  • 한수련 (경희대학교 한의과대학 신계내과학교실그룹) ;
  • 안영민 (경희대학교 한의과대학 신계내과학교실그룹) ;
  • 안세영 (경희대학교 한의과대학 신계내과학교실그룹) ;
  • 이병철 (경희대학교 한의과대학 신계내과학교실그룹)
  • Received : 2012.05.04
  • Accepted : 2012.09.12
  • Published : 2013.03.31
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Abstract

Objectives: This study was designed to investigate the anti-obesity, anti-diabetic and anti-inflammatory effects of Platycodi radix on obese type 2 diabetes mouse model. Methods: Obese type 2 diabetes mouse model was induced by Surwit's high fat, high sucrose diet for 8 weeks. Models were divided into 4 groups of normal diet (ND, n=10), high fat and high sucrose diet (HFD, n=10), high fat and high sucrose diet with Platycodi radix (PR, n=10), and high fat and high sucrose diet with Metformin (Met, n=10). Body weights were measured every week. After 7 weeks fasting, blood sugar and oral glucose tolerance tests were conducted. After 8 weeks blood samples were taken from mouse hearts and analyzed biochemically. Lipid profile, fructosamine, leptin and weight of epididymal fat pad and liver were measured. Adipose tissue macrophage percentage was analyzed by fluorescence-activated cell sorting (FACS). Results: Compared with the HFD group, body weight, glucose level, fructosamine, weight of epididymal fat pad and adipose tissue macrophage percentage decreased in the PR group. Conclusions: These results suggest that Platycodi Radix has anti-obesity, anti-diabetic, and anti-inflammatory effects on obese type 2 diabetes mouse model.

Keywords

Acknowledgement

Supported by : 경희대학교

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