Investigative Magnetic Resonance Imaging

Korean Society of Magnetic Resonance in Medicine (대한자기공명의과학회)
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Magnetic Resonance Imaging of Breast Cancer Patients with BRCA Mutation

BRCA 유전자 변이가 있는 유방암 환자의 자기공명영상

  • Chung, Sun Young (Department of Radiology and Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan) ;
  • Cha, Joo Hee (Department of Radiology and Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan) ;
  • Kim, Hak Hee (Department of Radiology and Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan) ;
  • Shin, Hee Jung (Department of Radiology and Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan) ;
  • Kim, Hyun Ji (Department of Radiology and Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan) ;
  • Chae, Eun Young (Department of Radiology and Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan) ;
  • Shin, Ji Eun (Department of Radiology and Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan) ;
  • Choi, Woo Jung (Department of Radiology and Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan) ;
  • Hong, Min Ji (Department of Radiology and Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan) ;
  • Ahn, Sei Hyun (Department of General Surgery, Asan Medical Center, College of Medicine, University of Ulsan) ;
  • Lee, Jong Won (Department of General Surgery, Asan Medical Center, College of Medicine, University of Ulsan) ;
  • Jung, Kyung Hae (Department of Internal Medicine, Asan Medical Center, College of Medicine, University of Ulsan)
  • 정선영 (울산대학교 의과대학 서울아산병원 영상의학과, 영상의학연구소) ;
  • 차주희 (울산대학교 의과대학 서울아산병원 영상의학과, 영상의학연구소) ;
  • 김학희 (울산대학교 의과대학 서울아산병원 영상의학과, 영상의학연구소) ;
  • 신희정 (울산대학교 의과대학 서울아산병원 영상의학과, 영상의학연구소) ;
  • 김현지 (울산대학교 의과대학 서울아산병원 영상의학과, 영상의학연구소) ;
  • 채은영 (울산대학교 의과대학 서울아산병원 영상의학과, 영상의학연구소) ;
  • 신지은 (울산대학교 의과대학 서울아산병원 영상의학과, 영상의학연구소) ;
  • 최우정 (울산대학교 의과대학 서울아산병원 영상의학과, 영상의학연구소) ;
  • 홍민지 (울산대학교 의과대학 서울아산병원 영상의학과, 영상의학연구소) ;
  • 안세현 (울산대학교 의과대학 서울아산병원 일반외과) ;
  • 이종원 (울산대학교 의과대학 서울아산병원 일반외과) ;
  • 정경해 (울산대학교 의과대학 서울아산병원 내과)
  • Received : 2013.08.22
  • Accepted : 2013.09.23
  • Published : 2013.09.30
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Abstract

Purpose : To evaluate the MRI findings of breast cancer with BRCA mutation. Materials and Methods: We collected information of the breast cancer patients who underwent the test for BRCA gene mutation as well as preoperative breast MRI from January 2007 to December 2010. A total of 185 patients were enrolled; 33 of these patients had BRCA mutations and 152 patients did not. Among them, a total of 231 breast cancers were detected. Images of the 47 breast cancers with BRCA mutation and of the 184 breast cancers without mutations were evaluated to compare the morphologic and enhancement features on MRI. Results: With MR imaging, there were no significant difference in morphologic characteristic between two groups. However, enhancement pattern in the group with BRCA mutation were more likely to have persistent enhancement (p < 0.233), and LN metastasis was more common in breast cancers without BRCA mutation. Breast cancers with BRCA 2 mutation tend to show more persistent enhancement pattern than BRCA 1 mutation. Conclusion: In breast cancer patients with BRCA mutation, MRI didn't show significant difference in morphologic characteristics, however breast cancers with BRCA gene mutation carriers tend to have benign morphologic features on MRI, such as Type 1 kinetic curve enhancement.

목적: BRCA 유전자 변이가 있는 유방암의 MRI 소견을 알아보고자 하였다. 대상과 방법: 2007년 1월에서 2010년 12월 사이에 BRCA 유전자 검사와 수술전 유방 MRI를 시행한 185명의 유방암 환자를 대상으로 하였다. 그 중 33명은 유전자 변이가 있었고 152명은 유전자 변이가 없었다. 총 231개의 유방암이 발견되었고, 유전자 변이가 있었던 환자의 47개의 유방암과 변이가 없었던 환자의 184개의 유방암에 대하여 MRI에서의 형태 및 조영증강 양상을 비교하였다. 결과: MRI에서의 유방암의 형태는 두 환자군 간에 유의한 차이가 없었다. 그러나 조영증강은 BRCA 유전자 변이가 있는 환자군에서 지속형을 보이는 경우가 더 많았고 (p < 0.233), 림프절 전이는 유전자 변이가 없는 환자군에서 더 많았다. BRCA 2 유전자 변이 환자군에서 BRCA 1 유전자 변이 환자군보다 지속형 조영증강을 보이는 경우가 더 많았다. 결론: MRI에서 BRCA 유전자 변이가 있는 유방암은 변이가 없는 유방암과 형태에서 유의한 차이를 보이지 않았으나 지속형 조영증강과 같이 양성종괴에서 보이는 형태학적 특징을 보이는 경우가 더 많았다.

Keywords

References

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