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우연히 발견된 부신피질 과립세포종 1예

Case of Incidental Oncocytic Adrenocortical Neoplasm

  • 김동현 (경희대학교 의학전문대학원 내분비대사 내과학교실) ;
  • 성지연 (경희대학교 의학전문대학원 병리학교실) ;
  • 이상열 (경희대학교 의학전문대학원 내분비대사 내과학교실) ;
  • 박소영 (경희대학교 의학전문대학원 내분비대사 내과학교실) ;
  • 손정일 (경희대학교 의학전문대학원 내분비대사 내과학교실) ;
  • 진상욱 (경희대학교 의학전문대학원 내분비대사 내과학교실) ;
  • 전숙 (경희대학교 의학전문대학원 내분비대사 내과학교실)
  • Kim, Dong Hyun (Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine) ;
  • Sung, Ji Youn (Department of Pathology, Kyung Hee University School of Medicine) ;
  • Rhee, Sang Youl (Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine) ;
  • Park, So Young (Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine) ;
  • Son, Jung Il (Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine) ;
  • Chin, Sang Ouk (Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine) ;
  • Chon, Suk (Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine)
  • 투고 : 2012.06.22
  • 심사 : 2012.10.19
  • 발행 : 2013.04.01

초록

부신피질 과립세포종은 매우 드문 부신종양으로, 대개 비기능성이기 때문에 우연히 발견되는 경우가 많다. 최근 저자들은 고혈압 병력을 가진 54세 남성에서 좌측부신에 위치하는 양성 비기능성 부신피질 과립세포종을 경험하였다. 이에 이번 증례와 함께 최근 발표된 문헌들에 대한 고찰을 하였다. 그 희귀성에도 불구하고 부신피질 과립세포종은 부신종양의 진단 시 반드시 감별하여야 하는데 이는 양성과 악성의 분류기준의 차이 및 예후의 차이 등에 기인하며 이를 위하여 임상소견, 생화학적 검사 및 조직학적 특징에 대한 평가가 필요하다.

Adrenal oncocytomas are very rare. Because most of them are benign and nonfunctioning, they are detected incidentally. Here, we report a case of nonfunctioning benign adrenocortical oncocytoma located in the left adrenal gland in a 54-year-old man who presented with no symptoms. The tumor was 4.5 ${\times}$ 3 ${\times}$ 3 cm in size and was predominantly composed of oncocytes, which exhibited abundant eosinophilic granular cytoplasm and were arranged with a nested or diffuse architecture without capsular or vascular invasion. Nuclear atypia and mitotic figures were not observed. A discussion of this case and a review of recent updates in the literature are presented. In patients with adrenocortical oncocytomas, treatment is similar to that for adrenocortical neoplasia. However, due to the risk of over-diagnosis of malignancy, and the better clinical outcomes associated with adrenocortical oncocytoma, more attention should be paid to the diagnosis of adrenocortical oncocytoma.

키워드

참고문헌

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