The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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A Case of Hemolytic Uremic Syndrome after Transarterial Chemoembolization with Cisplatin

시스플라틴을 이용한 경동맥 화학색전술 후 발생한 용혈성 요독증후군 1예

  • Yang, Jee Eun (Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Kang Mo (Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Shim, Ju Hyun (Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lim, Young-Suk (Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Han Chu (Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Chung, Young-Hwa (Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Yung Sang (Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine)
  • 양지은 (울산대학교 의과대학 서울아산병원 소화기내과) ;
  • 김강모 (울산대학교 의과대학 서울아산병원 소화기내과) ;
  • 심주현 (울산대학교 의과대학 서울아산병원 소화기내과) ;
  • 임영석 (울산대학교 의과대학 서울아산병원 소화기내과) ;
  • 이한주 (울산대학교 의과대학 서울아산병원 소화기내과) ;
  • 정영화 (울산대학교 의과대학 서울아산병원 소화기내과) ;
  • 이영상 (울산대학교 의과대학 서울아산병원 소화기내과)
  • Received : 2012.07.30
  • Accepted : 2012.10.24
  • Published : 2013.07.01
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Abstract

Hemolytic uremic syndrome (HUS) is a rare disorder characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. These characteristics are related to the formation of platelet-rich microthrombi in the microvasculature. HUS is associated with a variety of etiologies, including cisplatin. Previously reported HUS cases after cisplatin administration were almost always related to systemic combination chemotherapy that included cisplatin. Transarterial chemoembolization (TACE) is commonly used in treatment of hepatocellular carcinoma, and most centers in Korea use cisplatin. A 70-year-old female with hepatocellular carcinoma was treated with TACE including cisplatin and subsequently developed clinical and laboratory findings compatible with HUS.

Keywords

References

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