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Delayed-Onset Complete Atrioventricular Block in a Patient with Murine Typhus Myocarditis

발진열 심근염의 늦은 회복기에 발생한 완전방실전도차단 1예

  • Kim, Bo Sung (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Kim, Su Young (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Han, Seung Hee (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Park, He Kyung (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Lee, Dong Hyun (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Park, Jong Sung (Department of Internal Medicine, Dong-A University College of Medicine)
  • 김보성 (동아대학교 의과대학 내과학교실) ;
  • 김수영 (동아대학교 의과대학 내과학교실) ;
  • 한승희 (동아대학교 의과대학 내과학교실) ;
  • 박혜경 (동아대학교 의과대학 내과학교실) ;
  • 이동현 (동아대학교 의과대학 내과학교실) ;
  • 박종성 (동아대학교 의과대학 내과학교실)
  • Received : 2012.06.24
  • Accepted : 2012.09.12
  • Published : 2013.05.01

Abstract

Murine typhus is a flea-borne infectious disease caused by Rickettsia typhi, of which myocarditis is a rare complication in the acute disseminating phase. A 62-year-old female presented with a fever and was diagnosed with murine typhus. She was treated with doxycycline and discharged after complete resolution of the fever. However, recurrent presyncope and exertional dyspnea developed 6-8 weeks later. Complete atrioventricular (AV) block with a wide QRS escape rhythm and a left bundle branch block configuration was documented. Subacute myocarditis was diagnosed based on persistent cardiac troponin-I elevation and typical cardiac magnetic resonance imaging findings. A permanent pacemaker was implanted for symptomatic complete AV block. Few reports of myocarditis in murine typhus have been published. We report a case of murine typhus myocarditis complicated by complete AV block in the late convalescence phase.

2개월간의 발열을 주소로 입원한 62세의 여자 환자가 발진열로 진단받고 doxycycline 치료 후 회복되어 퇴원하였으나 6-8주 후부터 어지럼증 및 운동 시 호흡곤란이 발생하였으며 좌각차단 형태의 넓은 QRS파 이탈율동을 동반한 완전방실차단이 확인되었다. 심근 트로포닌-I 수치의 지속적인 상승과 특징적인 심장자기공명영상 소견에 따라 아급성 심근염 및 염증 후 섬유화에 의해 유발된 완전방실전도차단으로 진단하였으며, 방실전도차단이 지속되어 영구형 인공심박 조율기를 삽입하여 치료하였다. 발진열은 리케차티피에 의해 유발되는 벼룩매개 감염 질환이며 드물지만 발진열의 급성 파종기에 심근염 등의 합병증이 발생하는 것으로 보고되었다. 저자들은 리케차티피 감염 후 발생한 심근염과 염증 후 섬유화에 의해 늦은 회복기에 발생한 완전방실전도차단을 경험하였으며 이를 문헌고찰과 함께 보고하는 바이다.

Keywords

References

  1. Shah SS, McGowan JP. Rickettsial, ehrlichial and Bartonella infections of the myocardium and pericardium. Front Biosci 2003;8:e197-201. https://doi.org/10.2741/995
  2. Lamotte M, Labrousse C, Rozenbaum H, Normand JP. Myopericarditis with relapses related to murine typhus. Sem Hop 1965;41:518-522.
  3. Walker DH, Parks FM, Betz TG, Taylor JP, Muehlberger JW. Histopathology and immunohistologic demonstration of the distribution of Rickettsia typhi in fatal murine typhus. Am J Clin Pathol 1989;91:720-724. https://doi.org/10.1093/ajcp/91.6.720
  4. Chun CH, Chung HY. Three cases of murine typhus confirmed in Korea. Korean J Med 1959;2:87-90.
  5. Civen R, Ngo V. Murine typhus: an unrecognized suburban vectorborne disease. Clin Infect Dis 2008;46:913-918. https://doi.org/10.1086/527443
  6. Yotsukura M, Aoki N, Fukuzumi N, Ishikawa K. Review of a case of tsutsugamushi disease showing myocarditis and confirmation of Rickettsia by endomyocardial biopsy. Jpn Circ J 1991;55:149-153. https://doi.org/10.1253/jcj.55.149
  7. Magnani JW, Dec GW. Myocarditis: current trends in diagnosis and treatment. Circulation 2006;113:876-890. https://doi.org/10.1161/CIRCULATIONAHA.105.584532
  8. Cooper LT, Baughman KL, Feldman AM, et al. The role of endomyocardial biopsy in the management of cardiovascular disease: a scientific statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology. Circulation 2007;116: 2216-2233. https://doi.org/10.1161/CIRCULATIONAHA.107.186093
  9. Abdel-Aty H, Boye P, Zagrosek A, et al. Diagnostic performance of cardiovascular magnetic resonance in patients with suspected acute myocarditis: comparison of different approaches. J Am Coll Cardiol 2005;45:1815-1822. https://doi.org/10.1016/j.jacc.2004.11.069
  10. Lee N, Ip M, Wong B, et al. Risk factors associated with life-threatening rickettsial infections. Am J Trop Med Hyg 2008;78:973-978.
  11. Buchs AE, Zimlichman R, Sikuler E, Goldfarb B. Murine typhus endocarditis. South Med J 1992;85:751-753. https://doi.org/10.1097/00007611-199207000-00019
  12. Waring WS, Good AM, Bateman DN. Lack of significant toxicity after mirtazapine overdose: a five-year review of cases admitted to a regional toxicology unit. Clin Toxicol (Phila) 2007;45:45-50. https://doi.org/10.1080/15563650601005837
  13. Service JA, Waring WS. QT Prolongation and delayed atrioventricular conduction caused by acute ingestion of trazodone. Clin Toxicol (Phila) 2008;46:71-73. https://doi.org/10.1080/15563650701275322