The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Allergic Rhinitis and Comorbidities

알레르기 비염의 동반질환

  • Choi, Jeong-Hee (Department of Internal Medicine, Hallym University College of Medicine)
  • 최정희 (한림대학교 의과대학 내과학교실)
  • Published : 2013.11.01
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Abstract

Allergic rhinitis (AR) is a symptomatic disorder of the nose based on chronic allergic inflammation. AR is a global health problem that causes major illness and disability and inadequately treated, of which prevalence is about 20% of general population. In general, AR is rarely found in isolation and has been associated with numerous comorbidities, including bronchial asthma, allergic conjunctivitis, otitis media with effusion, sinusitis with polyp, chronic cough, adenoid hypertrophy and consequent sleep disturbance. In particular, coexistence of AR and asthma is a common feature, suggesting the concept of 'one airway, one disease'. Poorly controlled AR can develop or trigger exacerbations of these comorbidities because they often share pathophysiologic pathways in common with AR. Thus, AR should be regarded as a spectrum of systemic disease and treatment requires a systemic approach with considering its comorbidities.

Keywords

References

  1. Bousquet J, Khaltaev N, Cruz AA, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and Aller Gen). Allergy 2008;63(Suppl 86):8-160. https://doi.org/10.1111/j.1398-9995.2007.01620.x
  2. Lack G. Pediatric allergic rhinitis and comorbid disorders. J Allergy Clin Immunol 2001;108(1 Suppl):S9-15. https://doi.org/10.1067/mai.2001.115562
  3. Guerra S, Sherrill DL, Martinez FD, Barbee RA. Rhinitis as an independent risk factor for adult-onset asthma. J Allergy Clin Immunol 2002;109:419-425. https://doi.org/10.1067/mai.2002.121701
  4. Leynaert B, Neukirch C, Kony S, et al. Association between asthma and rhinitis according to atopic sensitization in a population-based study. J Allergy Clin Immunol 2004;113: 86-93. https://doi.org/10.1016/j.jaci.2003.10.010
  5. Bousquet J, Annesi-Maesano I, Carat F, et al. Characteristics of intermittent and persistent allergic rhinitis: DREAMS Study Group. Clin Exp Allergy 2005;35:728-732. https://doi.org/10.1111/j.1365-2222.2005.02274.x
  6. Ferdousi HA, Zetterström O, Dreborg S. Bronchial hyperresponsiveness predicts the development of mild clinical asthma within 2 yr in school children with hay-fever. Pediatr Allergy Immunol 2005;16:478-486. https://doi.org/10.1111/j.1399-3038.2005.00296.x
  7. Settipane RJ, Settipane GA. IgE and the allergy-asthma connection in the 23-year follow-up of Brown University students. Allergy Asthma Proc 2000;21:221-225. https://doi.org/10.2500/108854100778248890
  8. Bousquet J, Gaugris S, Kocevar VS, et al. Increased risk of asthma attacks and emergency visits among asthma patients with allergic rhinitis: a subgroup analysis of the investigation of montelukast as a partner agent for complementary therapy [corrected]. Clin Exp Allergy 2005;35:723-727. https://doi.org/10.1111/j.1365-2222.2005.02251.x
  9. Corren J, Manning BE, Thompson SF, Hennessy S, Strom BL. Rhinitis therapy and the prevention of hospital care for asthma: a case-control study. J Allergy Clin Immunol 2004; 113:415-419. https://doi.org/10.1016/j.jaci.2003.11.034
  10. Brozek JL, Bousquet J, Baena-Cagnani CE, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision. J Allergy Clin Immunol 2010;126:466-476. https://doi.org/10.1016/j.jaci.2010.06.047
  11. The Korean Academy of Asthma, Allergy and Clinical Immunology. Asthma and Allergic Diseases. 2nd ed. Seoul: Yeomoongak, 2012.
  12. Ono SJ, Abelson MB. Allergic conjunctivitis: update on pathophysiology and prospects for future treatment. J Allergy Clin Immunol 2005;115:118-122. https://doi.org/10.1016/j.jaci.2004.10.042
  13. Naclerio RM, deTineo ML, Baroody FM. Ragweed allergic rhinitis and the paranasal sinuses: a computed tomographic study. Arch Otolaryngol Head Neck Surg 1997;123:193-196. https://doi.org/10.1001/archotol.1997.01900020077011
  14. Piette V, Bousquet C, Kvedariene V, et al. Sinus CT scans and mediator release in nasal secretions after nasal challenge with cypress pollens. Allergy 2004;59:863-868. https://doi.org/10.1111/j.1398-9995.2004.00509.x
  15. Baroody FM, Suh SH, Naclerio RM. Total IgE serum levels correlate with sinus mucosal thickness on computerized tomography scans. J Allergy Clin Immunol 1997;100: 563-568. https://doi.org/10.1016/S0091-6749(97)70151-9
  16. Emanuel IA, Shah SB. Chronic rhinosinusitis: allergy and sinus computed tomography relationships. Otolaryngol Head Neck Surg 2000;123:687-691. https://doi.org/10.1067/mhn.2000.110961
  17. Yeo SG, Park DC, Eun YG, Cha CI. The role of allergic rhinitis in the development of otitis media with effusion: effect on eustachian tube function. Am J Otolaryngol 2007;28:148-152. https://doi.org/10.1016/j.amjoto.2006.07.011
  18. Nguyen LH, Manoukian JJ, Sobol SE, et al. Similar allergic inflammation in the middle ear and the upper airway: evidence linking otitis media with effusion to the united airways concept. J Allergy Clin Immunol 2004;114:1110- 1115. https://doi.org/10.1016/j.jaci.2004.07.061
  19. Huang SW, Giannoni C. The risk of adenoid hypertrophy in children with allergic rhinitis. Ann Allergy Asthma Immunol 2001;87:350-355. https://doi.org/10.1016/S1081-1206(10)62251-X
  20. Vinke JG, KleinJan A, Severijnen LW, Hoeve LJ, Fokkens WJ. Differences in nasal cellular infiltrates between allergic children and age-matched controls. Eur Respir J 1999;13: 797-803. https://doi.org/10.1034/j.1399-3003.1999.13d17.x
  21. Hadley JA, Derebery MJ, Marple BF. Comorbidities and allergic rhinitis: not just a runny nose. J Fam Pract 2012; 61(2 Suppl):S11-15.
  22. Yumoto E, Kozawa T, Yanagihara N. Influence of tonsillar hypertrophy to physical growth and diseases of the nose and ear in school-age children. Nihon Jibiinkoka Gakkai Kaiho 1991;94:534-540. https://doi.org/10.3950/jibiinkoka.94.534
  23. McColley SA, Carroll JL, Curtis S, Loughlin GM, Sampson HA. High prevalence of allergic sensitization in children with habitual snoring and obstructive sleep apnea. Chest 1997;111:170-173. https://doi.org/10.1378/chest.111.1.170

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