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Differentiation of Mass-Forming Autoimmune Pancreatitis from Pancreatic Cancer Using A 2-Week Steroid Trial

2주간의 스테로이드 투약을 통한 종괴 형성 자가면역 췌장염과 췌장암의 감별

  • Kim, Jeongseok (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Jin Yong (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kang, Dong-Uk (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Hocheol (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Moon, Min Young (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Won, Sunghyun (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Myung-Hwan (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine)
  • 김정석 (울산대학교 의과대학 서울아산병원 내과) ;
  • 김진용 (울산대학교 의과대학 서울아산병원 내과) ;
  • 강동욱 (울산대학교 의과대학 서울아산병원 내과) ;
  • 김호철 (울산대학교 의과대학 서울아산병원 내과) ;
  • 문민영 (울산대학교 의과대학 서울아산병원 내과) ;
  • 원성현 (울산대학교 의과대학 서울아산병원 내과) ;
  • 김명환 (울산대학교 의과대학 서울아산병원 내과)
  • Received : 2012.11.17
  • Accepted : 2012.11.22
  • Published : 2013.12.01

Abstract

The differentiation of mass-forming autoimmune pancreatitis (AIP) from pancreatic cancer is critical because AIP can be successfully treated with steroid therapy and unnecessary surgery avoided. We herein report a case of 69-year-old male with a prior history of recurrent AIP who developed a pancreatic body mass with upstream duct dilatation. Laboratory findings were nonspecific for AIP or pancreatic cancer, although an endoscopic ultrasonography-guided biopsy revealed chronic inflammation. To differentiate mass-forming AIP from pancreatic cancer, we administered oral steroids for 2 weeks. After steroid therapy, a computed tomography scan revealed a decrease in the pancreatic mass size and improvement in dilatation of the upstream duct. So we could differentiate mass-forming AIP from pancreatic cancer; thereafter resolution of pancreatic lesion could be achieved with further steroid therapy. In conclusion, a 2-week steroid trial followed by radiologic imaging was helpful to differentiate mass-forming AIP from pancreatic cancer.

췌장 종괴로 발현하는 자가면역 췌장염은 췌장암과의 감별이 매우 중요한데, 이는 스테로이드에 대한 치료 반응이 매우 좋아 불필요한 수술을 피할 수 있기 때문이다. 이번 증례에서는 재발성 자가면역 췌장염의 병력이 있는 환자에서 발견된 국소 췌장 종괴 및 상류쪽 주췌관의 확장 소견에 대해 2주간의 경구 스테로이드를 투약한 후 복부 CT를 시행한 결과, 췌장 종괴의 크기 감소와 주췌관 확장의 호전을 확인하였다. 이를 통해 자가면역 췌장염과 췌장암의 감별 진단에 도움을 얻었다. 이후 지속적으로 경구 스테로이드를 투약하면서 병변이 거의 소실된 것을 확인하였고 자가면역 췌장염을 확진할 수 있었다. 경구 스테로이드를 2주간 투약한 후, 영상 의학 검사를 통한 치료 반응 평가를 통해 종괴 형성 자가면역 췌장염과 췌장암의 감별 진단에 도움을 얻었던 증례이다.

Keywords

References

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