DOI QR코드

DOI QR Code

A Fatal Case of Naegleria fowleri Meningoencephalitis in Taiwan

  • Su, Mei-Yu (Clinical Laboratory, Chung Shan Medical University Hospital, Taichung) ;
  • Lee, Ming-Shih (Clinical Laboratory, Chung Shan Medical University Hospital, Taichung) ;
  • Shyu, Ling-Yuh (Department of Parasitology, Chung Shan Medical University) ;
  • Lin, Wei-Chen (Center for Research and Diagnostics, Centers for Disease Control) ;
  • Hsiao, Pei-Ching (Department of Internal Medicine, Chung Shan Medical University Hospital) ;
  • Wang, Chi-Ping (Clinical Laboratory, Chung Shan Medical University Hospital, Taichung) ;
  • Ji, Dar-Der (Center for Research and Diagnostics, Centers for Disease Control) ;
  • Chen, Ke-Min (Department of Parasitology, Chung Shan Medical University) ;
  • Lai, Shih-Chan (Department of Parasitology, Chung Shan Medical University)
  • 투고 : 2012.06.19
  • 심사 : 2012.07.26
  • 발행 : 2013.04.30

초록

After bathing at a hot spring resort, a 75-year-old man presented to the emergency department because of seizure-like attack with loss of conscious. This is the first case of primary amebic meningoencephalitis (PAM) caused by Naegleria fowleri in Taiwan. PAM was diagnosed based on detection of actively motile trophozoites in cerebrospinal fluid using a wet-mount smear and the Liu's stain. The amoebae were further confirmed by PCR and gene sequencing. In spite of administering amphotericin B treatment, the patient died 25 days later.

키워드

참고문헌

  1. Schuster FL, Visvesvara GS. Free-living amoebae as opportunistic and non-opportunistic pathogens of humans and animals. Int J Parasitol 2004; 34: 1001-1027. https://doi.org/10.1016/j.ijpara.2004.06.004
  2. Visvesvara GS, Moura H, Schuster FL. Pathogenic and opportunistic free-living amoebae: Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri, and Sappinia diploidea. FEMS Immunol Med Microbiol 2007; 50: 1-26. https://doi.org/10.1111/j.1574-695X.2007.00232.x
  3. da Rocha-Azevedo B, Tanowitz HB, Marciano-Cabral F. Diagnosis of infections caused by pathogenic free-living amoebae. Interdiscip Perspect Infect Dis 2009; 251406: 1-14.
  4. Heggie TW. Swimming with death: Naegleria fowleri infections in recreational waters. Travel Med Infect Dis 2010; 8: 201-206. https://doi.org/10.1016/j.tmaid.2010.06.001
  5. Martinez AJ, Visvesvara GS. Free-living, amphizoic and opportunistic amebas. Brain Pathol 1997; 7: 583-598. https://doi.org/10.1111/j.1750-3639.1997.tb01076.x
  6. Schild M, Gianinazzi C, Gottstein B, Müller N. PCR-based diagnosis of Naegleria sp. infection in formalin-fixed and paraffinembedded brain sections. J Clin Microbiol 2007; 45: 564-567. https://doi.org/10.1128/JCM.01357-06
  7. Qvarnstrom Y, Visvesvara GS, Sriram R, da Silva AJ. Multiplex real-time PCR assay for simultaneous detection of Acanthamoeba spp., Balamuthia mandrillaris, and Naegleria fowleri. J Clin Microbiol 2006; 44: 3589-3595. https://doi.org/10.1128/JCM.00875-06
  8. de Jonckheere J, Voorde H. The distribution of Naegleria fowleri in man-made thermal waters. Am J Trop Med Hyg 1977; 26: 10-15.
  9. Tyndall RL, Ironside KS, Metler PL, Tan EL, Hazen TC, Fliermans CB. Effect of thermal additions on the density and distribution of thermophilic amoebae and pathogenic Naegleria fowleri in a newly created cooling lake. Appl Environ Microbiol 1989; 55: 722-732.
  10. Kidney DD, Kim SH. CNS infections with free-living amebas: neuroimaging findings. AJR Am J Roentgenol 1998; 171: 809-812.
  11. Schumacher DJ, Tien RD, Lane K. Neuroimaging findings in rare amebic infections of the central nervous system. AJNR Am J Neuroradiol 1995; 16: 930-935.
  12. Carter RF. Sensitivity to amphotericin B of a Naegleria sp. isolated from a case of primary amoebic meningoencephalitis. J Clin Pathol 1969; 22: 470-474. https://doi.org/10.1136/jcp.22.4.470
  13. Vargas-Zepeda J, Gomez-Alcala AV, Vasquez-Morales JA, Licea-Amaya L, De Jonckheere JF, Lares-Villa F. Successful treatment of Naegleria fowleri meningoencephalitis by using intravenous amphotericin B, fluconazole and rifampicin. Arch Med Res 2005; 36: 83-86. https://doi.org/10.1016/j.arcmed.2004.11.003

피인용 문헌

  1. Review: Occurrence of the pathogenic amoeba Naegleria fowleri in groundwater vol.25, pp.4, 2017, https://doi.org/10.1007/s10040-017-1582-4
  2. Effects of Culture Media On Naegleria fowleri Growth At Different Temperatures vol.104, pp.5, 2013, https://doi.org/10.1645/18-6
  3. Exotic Tourist Destinations and Transmission of Infections by Swimming Pools and Hot Springs-A Literature Review vol.15, pp.12, 2018, https://doi.org/10.3390/ijerph15122730
  4. Naegleria fowleri: diagnosis, treatment options and pathogenesis vol.7, pp.2, 2019, https://doi.org/10.1080/21678707.2019.1571904
  5. Understanding the true burden of “Naegleria fowleri” (Vahlkampfiidae) in patients from Northern states of India: Source tracking and significance vol.76, pp.None, 2013, https://doi.org/10.1016/j.ejop.2020.125726