Korean Journal of Clinical Pharmacy (한국임상약학회지)

Korean College Of Clinical Pharmacy (한국임상약학회)
권호 표지

Drug Safety Perception and Medication Adherence in Pregnancy

임산부의 약물 인식 및 복약 순응도 조사연구

  • Received : 2013.08.27
  • Accepted : 2013.09.10
  • Published : 2013.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Background: Many factors including drugs, dietary supplements, and food intake can affect the development and organ formation of fetuses. Because of this, subject tends to avoid consuming things like coffee, alcohol, or cigarettes due to the risks they pose during pregnancy. Therefore, analysis of drugs and favorite food consumption is needed and important to ensure safe health management for subject. Purpose: This study was conducted domestically to analyze these factors in South Korea. Method: The survey was conducted from pregnancy-related online communities for six days and the survey results were received via email for analysis. Result: A total of 127 subjects answered the questionnaire via email; the characteristics of subjects are widely varied in their ages, education levels, job statuses, and residences. The questionnaire included the intake of dietary supplements during pregnancy including vitamins and the result showed that the subjects took 2.23 different kinds of supplements on average. In order of highest frequency, 101 subjects took multivitamins; 79 subjects took an iron supplement; 30 subjects took analgesics; 20 subjects took prescribed antipyretic and medication for upper respiratory diseases; 12 subjects took antibiotics; 7 subjects took antiemetics. Their compliances were different in each medication categories. Only 8% of subjects answered that they had asked a pharmacist for medication information during pregnancy. In addition, 78% of subjects answered that they never counseled with anyone about pregnancy related medication use. Conclusion: In conclusion, many subjects took medication including dietary supplements. The role of pharmacists should be actively developed to improve subject care such as education about subject's medication uses and their food consumption behavior.

Keywords

References

  1. Sadler TW. Langman's medical embryology. 10th ed. Baltimore: Lippincott Williams and Wilkins; 2006.
  2. Goh YI, Bollano E, Einarson TR, et al., Prenatal multivitamin supplementation and rates of congenital anomalies: a meta-analysis. J Obstet Gynaecol Can 2006; 28(8): 680.
  3. M Saaka. Combined Iron and Zinc Supplementation Improves Haematologic Status of Subject in Upper West Region of Ghana. Ghana Med J 2012; 46(4): 225-33.
  4. Hanieh S, Ha TT, Simpson JA, et al., The effect of intermittent antenatal iron supplementation on maternal and infant outcomes in rural viet nam: a cluster randomised trial. PLoS Med 2013;10(6): e1001470. doi: 10.1371/journal. pmed.1001470. Epub 2013 Jun 18
  5. Mozurkewich E, Chilimigras J, Klemens C, et al., The mothers, Omega-3 and mental health study. BMC Pregnancy Childbirth 2011; 11: 46. doi: 10.1186/1471-2393-11-46.
  6. O'Brien KO, Donangelo CM, Ritchie LD, et al., Serum 1,25-dihydroxyvitamin D and calcium intake affect rates of bone calcium deposition during pregnancy and the early postpartum period. Am J Clin Nutr 2012; 96(1): 64-72. https://doi.org/10.3945/ajcn.111.029231
  7. Chan KK, Chan BC, Lam KF, et al., Iron supplement in pregnancy and development of gestational diabetes-a randomised placebo-controlled trial. BJOG 2009;116(6): 789-97. https://doi.org/10.1111/j.1471-0528.2008.02014.x
  8. Chelchowska M, $Jab^3onka$-Salach K, Ambroszkiewicz J, et al., Effect of cigarette smoking on blood lead levels in subject. Med Wieku Rozwoj 2012;16(3):196-204.
  9. Buscicchio G, Piemontese M, Gentilucci L, et al., The effects of maternal caffeine and chocolate intake on fetal heart rate. J Matern Fetal Neonatal Med 2011; 25(5): 528-530.
  10. Jamie R Daw, Prescription drug use during pregnancy in developed countries: a systematic review. Pharmacoepidemiol Drug Saf 2011; 20(9): 895-902.
  11. Statistics Korea. http://kostat.go.kr (Last accessed on April 22, 2013)
  12. Andrade SE, Gurwitz JH, Davis RL, et al., Prescription drug use in pregnancy. Am J Obstet Gynecol 2004; 191(2): 398-407. https://doi.org/10.1016/j.ajog.2004.04.025
  13. Olesen C, Sorensen HT, de Jong-van den Berg LTW, et al., Prescribing during pregnancy and lactation with reference to the Swedish classification system: a population-based study among Danish women. Acta Obstet Gynecol Scand 1999; 78(8): 686-92. https://doi.org/10.1080/j.1600-0412.1999.780805.x
  14. Olesen C, Steffensen FH, Niesen GL, et al., Drug use in first pregnancy and lactation: a population-based survey among Danish women: the EUROMAP group. Eur J Clin Pharmacol 1999; 55(2): 139-44. https://doi.org/10.1007/s002280050608
  15. Lacroix I, Damase-Michel C, Lapeyre-Mestre M, et al., Prescription of drugs during pregnancy in France. Lancet 2000; 356: 1735-6. https://doi.org/10.1016/S0140-6736(00)03209-8
  16. Oliveira FA, Gama DP, Leopardi Md, et al., Self-reported adherence to prescribed medicines during pregnancy. Rev Bras Ginecol Obstet 34(4):147-52.
  17. Sawicki E, Stewart K, Wong S, et al., Medication use for chronic health conditions by subject attending an Australian maternity hospital. Aust N Z J Obstet Gynaecol 2011; 51(4): 333-8. https://doi.org/10.1111/j.1479-828X.2011.01312.x
  18. Rasmussen MM, Clemmensen D. Folic acid supplementation in subject. Dan Med Bull 2010; 57(1): A4134.
  19. Nguyen P, Nava-Ocampo A, Levy A, et al., Effect of iron content on the tolerability of prenatal multivitamins in pregnancy. BMC Pregnancy Childbirth 2008; 15(8): 17-24.
  20. Koren G, Pairaideau N. Compliance with prenatal vitamins. Subjects with morning sickness sometimes find it difficult. Can Fam Physician 2006; 52(11): 1392-3.
  21. Dupraz J, Graff V, Barasche J, et al., Tobacco and alcohol during pregnancy: prevalence and determinants in Geneva in 2008. Swiss Med Wkly 2013; 25: 143-150.
  22. Jagielska I, Kazdepka-Zieminska A, Stankiewicz M, et al., Alcohol-woman, pregnancy and a newborn child. Przegl Lek 2012; 69(10): 1108-10.
  23. de Zeeuw P, Zwart F, Schrama R, et al., Prenatal exposure to cigarette smoke or alcohol and cerebellum volume in attention-deficit/hyperactivity disorder and typical development. Transl Psychiatry 2012; 2: 84-92. https://doi.org/10.1038/tp.2012.12