The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Total bilirubin level as a biomarker for dampness-heat differentiation in traditional Korean treatment for jaundice

  • Sohn, Ki Cheul (Department of Preventive Medicine, Catholic University of Daegu, School of Medicine) ;
  • Jung, Hyun-Jung (Department of Diagnostics, College of Korean Medicine, Daegu Hanny University Comprehensive Integrated Medicine Institute) ;
  • Lee, A-Jin (Department of Laboratory Medicine, Catholic University of Daegu, School of Medicine, Comprehensive Integrated Medicine Institute) ;
  • Kim, Sang-Gyung (Department of Laboratory Medicine, Catholic University of Daegu, School of Medicine) ;
  • Shin, ImHee (Department of Medical Statistics & Informatics, Catholic University of Daegu, School of Medicine) ;
  • Kwak, Sang Gyu (Department of Medical Statistics & Informatics, School of Medicine, Catholic University of Daegu, Comprehensive Integrated Medicine Institute)
  • Received : 2013.10.31
  • Accepted : 2013.12.18
  • Published : 2013.12.30
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Abstract

Objectives: Classifying the pattern of jaundice during diagnosis will significantly improve the outcome of common KM interventions. This study aimed at determining an objective index for accurately diagnosing heat and dampness KM patterns in patients with jaundice. Methods: We systematically reviewed laboratory findings from case reports published in the scientific literature of Korean medicine. Cases were classified as following either the heat or dampness pattern. Biochemical indices were compared using a Bayesian factor (BF) analysis and standard t-tests. Results: The laboratory findings of 32 patients were evaluated. The heat pattern was observed in 17 patients and the dampness pattern in 15. No significant differences were observed between the 2 groups in terms of white blood cell count (BF=1.659); hemoglobin concentration (BF=2.627); platelet count (BF=1.019); or levels of direct bilirubin (BF=1.453), aspartate aminotransferase (BF=1.226), alanine aminotransferase (BF=1.340), alkaline phosphatase (BF=2.344), or gamma-glutamyl transpeptidase (BF=2.782). However, total bilirubin levels were significantly higher in the dampness pattern group (BF=0.854, P-value=0.070). Conclusions: Patients with high total bilirubin levels may predominantly follow the dampness pattern, while those with low levels may predominantly follow the heat pattern. These results are expected to be useful for the development of timely and efficient KM treatments as well as new integrative therapeutic approaches for jaundice. However, further studies are essential to fully validate the utility of total bilirubin as a biomarker for differentiating between heat and dampness patterns.

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References

  1. Royal Australian College of General Practitioners. RACGP curriculum for Australian general practice. Curriculum statement: integrative medicine. 2007; Available at: URL:http://www.racgp.org.au/scriptcontent/curriculum/pdf/integrativemedicine.pdf. Accessed March 24, 2009.
  2. Horrigan B, Lewis S, Abrams DI, Pechura C. Integrative medicine in Americahow integrative medicine is being practiced in clinical centers across the United States. Global Advances in Health and Medicine 1.3. 2012:18-94.
  3. Lee SR. Medical services system cooperation between Western and Oriental medicine. The Journal of Daegu Health College. 2009;29:1-28.
  4. Rosenthal DS, Dean-Clower E. Integrative medicine in hematology/oncology: benefits, ethical considerations, and controversies. Hematology Am Soc Hematol Educ Program. 2005:491-497.
  5. Choi TY, Lee MS, Kim TH, Zaslawski C, Ernst E. Acupuncture for the treatment of cancer pain: a systematic review of randomised clinical trials. Support Care Cancer. 2012;20:147-58.
  6. Choi SM, Park JE, Li SS, Jung H, Zi M, Kim TH, et al. A multicenter, randomized, controlled trial testing the effects of acupuncture on allergic rhinitis. Allergy. 2013;68:365-374. https://doi.org/10.1111/all.12053
  7. Saleki M, Ahadi T, Razi M, Raeisi GR, Forough B, Ali MK. Comparison of the effects of acupuncture and isometric exercises on symptom of knee osteoarthritis. Int J Prev Med. 2013;4:S73-S77.
  8. Giordano J, Garcia MK, Strickland G. Integrating Chinese traditional medicine into a US public health paradigm. J Altern Complement Med. 2004;10:706-710. https://doi.org/10.1089/acm.2004.10.706
  9. Lu AP, Jia HW, Xiao C, Lu QP. Theory of traditional Chinese medicine and therapeutic method of diseases. World J Gastroenterol. 2004;10:1854-1856. https://doi.org/10.3748/wjg.v10.i13.1854
  10. Cha WS, Oh JH, Park HJ, Ahn SW, Hong SY, Kim NI. Historical difference between traditional Korean medicine and traditional Chinese medicine. Neurol Res. 2007;29 (Supplement 1):S5-S9. https://doi.org/10.1179/016164107X172293
  11. Lee SG. A comparative study on the differenced of mental illness between Korea and China in Oriental medicine. J of Oriental Neuropsychiatry. 2005;16:193-200.
  12. Kim DW. Disease pattern identification in Oriental medicine and herb medicine treatment for acute hepatitis A with jaundice: Case series of 3 patients. Korean J Oriental Physiology & Pathology. 2010;24:696-701.
  13. Kim HY, Jang SY, Yoon KM, Im EY, Yoo HJ, Choi GH, et al. A clinical report on 1 case of jaundice caused by the alcoholic liver disease. The Journal of East-West Medicine. 2009;34:37-44.
  14. Lee KS, Choi KJ, Lee TG, Koh BH, Song IB, Lee SK. A case study of soeumin jaundice patient diagnosed as drug-induced hepatitis. J of Sasan Constitut Med. 2005;17:99-106.
  15. Ferrucci LM, Bell BP, Dhotre KB, Manos MM, Terrault NA, Zaman A, et al. Complementary and alternative medicine use in chronic liver disease patients. J Clin Gastroenterol. 2010;44:e40-e45. https://doi.org/10.1097/MCG.0b013e3181b766ed
  16. Mullin GE. The use of complementary and alternative medicine for liver disease: Part I. Nutr Clin Pract. 2012;28:138-139.
  17. MacPherson H, Sinclair-Lian N, Thomas K. Patients seeking care from acupuncture practitioners in the UK: A national survey. Complement Ther Med. 2006;14:20-30. https://doi.org/10.1016/j.ctim.2005.07.006
  18. Lu C, Zha Q, Chang A, He Y, Lu A. Pattern differentiation in traditional Chinese medicine can help define specific indications for biomedical therapy in the treatment of rheumatoid arthritis. J Altern Complement Med. 2009;15:1021-5. https://doi.org/10.1089/acm.2009.0065
  19. Heo J. Dongguei bogam. 1st ed. Seoul:Bubinbooks. 1999:1345-53.
  20. Jeffreys H. Theory of Probability. USA:Oxford University Press. 1961:432-3.
  21. Albert J. Bayesian Computation With R. USA:Springer Science+Business Media. 2011:19-20.
  22. Lee MS, Shin B-C, Choi T-Y, Kim J-I. Randomized clinical trials on Eastern-Western integrative medicine for health care in Korean literature: A systematic review. Chin J Integr Med. 2011;17:4851.
  23. Nam DW, Choi YS, Kim HB, Kim JI, Lim S, Kim KS, et al. Randomized controlled trial of east-west collaborate medical treatment on female chronic shoulder pain patients. J Korean Acupunct Moxib Soc. 2007;24:113-122.
  24. Jung IT, Lee SH, Kim SY, Cha WH, Kim KS, Lee DI, et al. A clinical study of east-west pain treatment on chronic headache patients. J Korean Acupunct Moxib Soc 2005;22:93-104.
  25. Kwon NH, Shin YJ, Kim CY, Koh PS, Yi WI, Joh BJ, et al. Comparative clinical study between Oriental medicine and Oriental-Western medical treatment on Bell's palsy. J Korean Acupunct Moxib Soc. 2008;25:19-28.
  26. Kim Y-S, Wang J, Mann D, Gaylord S, Lee H-J, Lee M. Korean Oriental medicine in stroke care. Complement Health Pract Review. 2005;10:105-17. https://doi.org/10.1177/1533210105279482
  27. Wu XZ, Chen D. Study on objectivation of syndrome typing of jaundice. Zhongguo Zhong Xi Yi Jie He Za Zhi (Chin). 2005;25:773-6.
  28. Zhuo DT, Lu JY, Huang LP. Effect of modified huopoxialing decoction in treating pi-wei dampness-heat syndrome and its impact on the tongue epithelial cell apoptosis. Zhongguo Zhong Xi Yi Jie He Za Zhi (Chin). 2011;31:168-71.
  29. Garcea G, Ngu W, Neal CP, Dennison AR, Berry DP. Bilirubin levels predict malignancy in patients with obstructive jaundice. HPB (Oxford). 2011;13:426-30. https://doi.org/10.1111/j.1477-2574.2011.00312.x
  30. Nakata B, Amano R, Kimura K, Hirakawa K. Comparison of prognosis between patients of pancreatic head cancer with andwithout obstructive jaundice at diagnosis. Int J Surg 2013;doi: 10.1016/j.ijsu.2013.02.023.
  31. Xiang HL, Han T, Du Z, Li T, Li J, Lu HM, et al. Analysis of prognostic factors of severe jaundice patients using HB-H-6 resin plasma perfusion. Zhongguo Wei Zhong Bing JiJiu Yi Xue (Chin). 2012;24(6):3303.
  32. Thapa BR, Walia A. Liver function tests and their interpretation. Indian J Pediatr. 2007;74:66371.
  33. World Health Organization. WHO international standard terminologies on traditional medicine in the Western Pacific region. WHO Library Cataloguing in Publication Data. 2007.

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