Journal of Yeungnam Medical Science

Yeungnam University College of Medicine, Yeungnam University Institute Medical Science (영남대 의대 학술지 편집위원회)
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A Case of Metastatic Hepatocellular Carcinoma of the Orbit

간세포암종의 안와 전이 1예

  • Yang, Young-Joo (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Bae, Seung-Hyeon (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Jang, Il-Young (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Jun, Mi-Jung (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Jung, Ji-Won (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • An, Ji-Hyun (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Shim, Ju-Hyun (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine)
  • 양영주 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 배승현 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 장일영 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 전미정 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 정지원 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 안지현 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 심주현 (울산대학교 의과대학 서울아산병원 내과학교실)
  • Received : 2013.06.20
  • Accepted : 2013.07.24
  • Published : 2013.12.31
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Abstract

Orbital metastasis from hepatocellular carcinoma is very rare, with only 14 biopsy-proven cases from hepa tocellular carcinoma cases reported in English literature and three cases reported in Korea. Common symptoms of orbital metastasis are proptosis, visual loss, ocular pain and oculomotor dysfunction. For its precise diagnosis, we can perform fine needle aspiration biopsy, orbit CT or MRI, and ultrasonography. Radiotherapy is the mainstay in the treatment of orbital metastasis. In addition, chemotherapy, hormonal therapy and surgical intervention can play a role in the treatment of orbital metastasis according to the primary cancer and symptoms. However, the prognosis of orbital metastasis is poor. We report herein a rare case of a patient with orbital metastasis from hepatocellular carcinoma, which was treated with various modalities that included resection, and who had good clinical and radiological responses to radiation therapy and sorafenib (Nexavar, Bayer HealthCare).

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