Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Attunement Disorder : A Disorder of Brain Connectivity

조현병(調鉉病) : 뇌 연결성의 장애

  • 김기원 (용인정신병원 정신건강의학과) ;
  • 박경민 (용인정신병원 정신건강의학과) ;
  • 장혜련 (용인정신병원 정신건강의학과) ;
  • 이유상 (용인정신병원 정신건강의학과) ;
  • 박선철 (용인정신병원 정신건강의학과)
  • Received : 2013.09.30
  • Accepted : 2013.10.24
  • Published : 2013.11.30
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Abstract

Objectives We reviewed cellular and synaptic dysconnectivity, disturbances in micro- and macro- circuitries, and neurodevelopmentally-derived disruptions of neural connectivity in the pathogenesis of schizophrenia. Method We reviewed the selected articles about disturbances in neural circuits which had been proposed as a pathogenetic mechanism of schizophrenia. Results The literature review reveals that schizophrenia may be a disease related to disturbance in neurodevelopmental mechanism, shown as 'a misconnection syndrome of neural circuit or neural network'. In descriptive psychopathological view, definition of a disorder of brain connectivity has limitation to explain other aspects of schizophrenia including deterministic strictness in thought process. Conclusion Schizophrenia is considered as a disorder of brain connectivity as well as a neurodevelopmental disorder related with genetic and environmental factors. We could make a suggestion that "JoHyeonByung (attunement disorder)" denotes the disturbances of psychic fine-tuning which correspond to the neural correlates of brain dysconnectivity metaphorically.

Keywords

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