Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
권호 표지
DOI QR코드

DOI QR Code

Association of Selected Medical Conditions With Breast Cancer Risk in Korea

  • Jung, Sun Jae (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Song, Minkyo (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Choi, Ji-Yeob (Cancer Research Institute, Seoul National University College of Medicine) ;
  • Song, Nan (Cancer Research Institute, Seoul National University College of Medicine) ;
  • Park, Sue Kyung (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Yoo, Keun-Young (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Kang, Daehee (Department of Preventive Medicine, Seoul National University College of Medicine)
  • Received : 2013.08.01
  • Accepted : 2013.10.17
  • Published : 2013.11.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: To estimate the effect of medical conditions in the population of Korea on breast cancer risk in a case-control study. Methods: The cases were 3242 women with incident, histologically confirmed breast cancer in two major hospitals interviewed between 2001 and 2007. The controls were 1818 women each admitted to either of those two hospitals for a variety of non-neoplastic conditions. Information on each disease was obtained from a standardized questionnaire by trained personnel. Odds ratios (ORs) for each disease were derived from multiple logistic regression adjusted for age, age of menarche, pregnancy, age of first pregnancy, and family history of breast cancer. Results: Among all of the incident breast cancer patients, pre-existing diabetes (OR, 1.33; 95% confidence interval [CI], 0.99 to 1.78), hypertension (OR, 1.46; 95% CI, 1.18 to 1.83), thyroid diseases (OR, 1.26; 95% CI, 1.00 to 1.58), and ovarian diseases (OR, 1.70; 95% CI, 1.23 to 2.35) were associated with an increased risk of breast cancer when other factors were adjusted for. In a stratified analysis by menopausal status, pre-existing hypertension (pre-menopause OR, 0.80; 95% CI, 0.48 to 1.34 vs. post-menopause OR, 1.87; 95% CI, 1.44 to 2.43; p-heterogeneity <0.01) and ovarian disease (pre-menopause OR, 4.20; 95% CI, 1.91 to 9.24 vs. post-menopause OR, 1.39; 95% CI, 1.02 to 1.91; p-heterogeneity 0.01) showed significantly different risks of breast cancer. Conclusions: Our results suggest the possibility that medical conditions such as hypertension affect breast cancer development, and that this can differ by menopausal status. Our study also indicates a possible correlation between ovarian diseases and breast cancer risk.

Keywords

References

  1. Jung KW, Won YJ, Kong HJ, Oh CM, Seo HG, Lee JS. Prediction of cancer incidence and mortality in Korea, 2013. Cancer Res Treat 2013;45(1):15-21. https://doi.org/10.4143/crt.2013.45.1.15
  2. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin 2012;62(1):10-29. https://doi.org/10.3322/caac.20138
  3. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011;61(2):69-90. https://doi.org/10.3322/caac.20107
  4. Kohler BA, Ward E, McCarthy BJ, Schymura MJ, Ries LA, Eheman C, et al. Annual report to the nation on the status of cancer, 1975-2007, featuring tumors of the brain and other nervous system. J Natl Cancer Inst 2011;103(9):714-736. https://doi.org/10.1093/jnci/djr077
  5. Nichols HB, Berrington de González A, Lacey JV Jr, Rosenberg PS, Anderson WF. Declining incidence of contralateral breast cancer in the United States from 1975 to 2006. J Clin Oncol 2011;29(12):1564-1569. https://doi.org/10.1200/JCO.2010.32.7395
  6. Kelsey JL, Gammon MD, John EM. Reproductive factors and breast cancer. Epidemiol Rev 1993;15(1):36-47.
  7. Collaborative Group on Hormonal Factors in Breast Cancer. Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58,209 women with breast cancer and 101,986 women without the disease. Lancet 2001;358(9291):1389-1399. https://doi.org/10.1016/S0140-6736(01)06524-2
  8. Henderson TO, Amsterdam A, Bhatia S, Hudson MM, Meadows AT, Neglia JP, et al. Systematic review: surveillance for breast cancer in women treated with chest radiation for childhood, adolescent, or young adult cancer. Ann Intern Med 2010; 152(7):444-455. https://doi.org/10.7326/0003-4819-152-7-201004060-00009
  9. Singletary KW, Gapstur SM. Alcohol and breast cancer: review of epidemiologic and experimental evidence and potential mechanisms. JAMA 2001;286(17):2143-2151. https://doi.org/10.1001/jama.286.17.2143
  10. Reynolds P, Hurley S, Goldberg DE, Anton-Culver H, Bernstein L, Deapen D, et al. Active smoking, household passive smoking, and breast cancer: evidence from the California Teachers Study. J Natl Cancer Inst 2004;96(1):29-37. https://doi.org/10.1093/jnci/djh002
  11. Bernstein L, Ross RK. Endogenous hormones and breast cancer risk. Epidemiol Rev 1993;15(1):48-65. https://doi.org/10.1093/oxfordjournals.epirev.a036116
  12. Goldman MB. Thyroid diseases and breast cancer. Epidemiol Rev 1990;12:16-28. https://doi.org/10.1093/oxfordjournals.epirev.a036051
  13. Weiss HA, Brinton LA, Potischman NA, Brogan D, Coates RJ, Gammon MD, et al. Breast cancer risk in young women and history of selected medical conditions. Int J Epidemiol 1999; 28(5):816-823. https://doi.org/10.1093/ije/28.5.816
  14. Larsson SC, Mantzoros CS, Wolk A. Diabetes mellitus and risk of breast cancer: a meta-analysis. Int J Cancer 2007;121(4): 856-862. https://doi.org/10.1002/ijc.22717
  15. Peeters PH, van Noord PA, Hoes AW, Fracheboud J, Gimbrère CH, Grobbee DE. Hypertension and breast cancer risk in a 19-year follow-up study (the DOM cohort). Diagnostic investigation into mammarian cancer. J Hypertens 2000;18(3):249-254. https://doi.org/10.1097/00004872-200018030-00002
  16. Vojtechova P, Martin RM. The association of atopic diseases with breast, prostate, and colorectal cancers: a meta-analysis. Cancer Causes Control 2009;20(7):1091-1105. https://doi.org/10.1007/s10552-009-9334-y
  17. Wiseman H, Halliwell B. Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Biochem J 1996;313(Pt 1):17-29.
  18. Chung S, Park SK, Sung H, Song N, Han W, Noh DY, et al. Association between chronological change of reproductive factors and breast cancer risk defined by hormone receptor status: results from the Seoul Breast Cancer Study. Breast Cancer Res Treat 2013;140(3):557-565. https://doi.org/10.1007/s10549-013-2645-4
  19. Choi JY, Lee KM, Park SK, Noh DY, Ahn SH, Yoo KY, et al. Association of paternal age at birth and the risk of breast cancer in offspring: a case control study. BMC Cancer 2005;5:143. https://doi.org/10.1186/1471-2407-5-143
  20. Largent JA, McEligot AJ, Ziogas A, Reid C, Hess J, Leighton N, et al. Hypertension, diuretics and breast cancer risk. J Hum Hypertens 2006;20(10):727-732. https://doi.org/10.1038/sj.jhh.1002075
  21. Nordén A, Scherstén B, Thulin T, Pero RW, Bryngelsson C, Mitelman F. Letter: Hypertension related to D.N.A. repair synthesis and carcinogen uptake. Lancet 1975;2(7944):1094.
  22. Hamet P. Cancer and hypertension: a potential for crosstalk? J Hypertens 1997;15(12 Pt 2):1573-1577. https://doi.org/10.1097/00004872-199715120-00058
  23. Kaaks R. Nutrition, hormones, and breast cancer: is insulin the missing link? Cancer Causes Control 1996;7(6):605-625. https://doi.org/10.1007/BF00051703
  24. Soler M, Chatenoud L, Negri E, Parazzini F, Franceschi S, la Vecchia C. Hypertension and hormone-related neoplasms in women. Hypertension 1999;34(2):320-325. https://doi.org/10.1161/01.HYP.34.2.320
  25. Jee SH, Ohrr H, Sull JW, Yun JE, Ji M, Samet JM. Fasting serum glucose level and cancer risk in Korean men and women. JAMA 2005;293(2):194-202. https://doi.org/10.1001/jama.293.2.194
  26. Wideroff L, Gridley G, Mellemkjaer L, Chow WH, Linet M, Keehn S, et al. Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark. J Natl Cancer Inst 1997;89(18):1360-1365. https://doi.org/10.1093/jnci/89.18.1360
  27. Cannata D, Fierz Y, Vijayakumar A, LeRoith D. Type 2 diabetes and cancer: what is the connection? Mt Sinai J Med 2010;77(2): 197-213. https://doi.org/10.1002/msj.20167
  28. Van der Burg B, Rutteman GR, Blankenstein MA, de Laat SW, van Zoelen EJ. Mitogenic stimulation of human breast cancer cells in a growth factor-defined medium: synergistic action of insulin and estrogen. J Cell Physiol 1988;134(1):101-108. https://doi.org/10.1002/jcp.1041340112
  29. Rose DP, Komninou D, Stephenson GD. Obesity, adipocytokines, and insulin resistance in breast cancer. Obes Rev 2004; 5(3):153-165. https://doi.org/10.1111/j.1467-789X.2004.00142.x
  30. Peyrat JP, Bonneterre J, Hecquet B, Vennin P, Louchez MM, Fournier C, et al. Plasma insulin-like growth factor-1 (IGF-1) concentrations in human breast cancer. Eur J Cancer 1993; 29A(4):492-497.
  31. Oliveras-Ferraros C, Cufí S, Vazquez-Martin A, Torres-Garcia VZ, Del Barco S, Martin-Castillo B, et al. Micro(mi)RNA expression profile of breast cancer epithelial cells treated with the anti-diabetic drug metformin: induction of the tumor suppressor miRNA let-7a and suppression of the TGF$\beta$-induced oncomiR miRNA-181a. Cell Cycle 2011;10(7):1144-1151. https://doi.org/10.4161/cc.10.7.15210
  32. Ron E, Curtis R, Hoffman DA, Flannery JT. Multiple primary breast and thyroid cancer. Br J Cancer 1984;49(1):87-92. https://doi.org/10.1038/bjc.1984.13
  33. Stewart AJ, Johnson MD, May FE, Westley BR. Role of insulin-like growth factors and the type I insulin-like growth factor receptor in the estrogen-stimulated proliferation of human breast cancer cells. J Biol Chem 1990;265(34):21172-21178.
  34. Turken O, NarIn Y, DemIrbas S, Onde ME, Sayan O, KandemIr EG, et al. Breast cancer in association with thyroid disorders. Breast Cancer Res 2003;5(5):R110-R113. https://doi.org/10.1186/bcr609
  35. Giani C, Fierabracci P, Bonacci R, Gigliotti A, Campani D, De Negri F, et al. Relationship between breast cancer and thyroid disease: relevance of autoimmune thyroid disorders in breast malignancy. J Clin Endocrinol Metab 1996;81(3):990-994.
  36. Metindir J, Aslan S, Bilir G. Ovarian cyst formation in patients using tamoxifen for breast cancer. Jpn J Clin Oncol 2005;35(10): 607-611. https://doi.org/10.1093/jjco/hyi165
  37. Clemons M, Goss P. Estrogen and the risk of breast cancer. N Engl J Med 2001;344(4):276-285. https://doi.org/10.1056/NEJM200101253440407
  38. Olive DL, Schwartz LB. Endometriosis. N Engl J Med 1993; 328(24):1759-1769. https://doi.org/10.1056/NEJM199306173282407
  39. Giudice LC, Kao LC. Endometriosis. Lancet 2004;364(9447): 1789-1799. https://doi.org/10.1016/S0140-6736(04)17403-5
  40. Brinton LA, Gridley G, Persson I, Baron J, Bergqvist A. Cancer risk after a hospital discharge diagnosis of endometriosis. Am J Obstet Gynecol 1997;176(3):572-579. https://doi.org/10.1016/S0002-9378(97)70550-7

Cited by

  1. Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patients: a systemic review and meta-analysis vol.9, pp.1, 2013, https://doi.org/10.1186/1746-1596-9-91
  2. Detection of MMTV-Like sequences in Moroccan breast cancer cases vol.9, pp.1, 2013, https://doi.org/10.1186/1750-9378-9-37
  3. Associations between Medical Conditions and Breast Cancer Risk in Asians: A Nationwide Population-Based Study in Taiwan vol.10, pp.11, 2015, https://doi.org/10.1371/journal.pone.0143410
  4. Detection of human papillomavirus DNA in tumors from Rwandese breast cancer patients vol.25, pp.2, 2018, https://doi.org/10.1007/s12282-018-0831-2
  5. Association between blood pressure and risk of cancer development: a systematic review and meta-analysis of observational studies vol.9, pp.None, 2019, https://doi.org/10.1038/s41598-019-45014-4
  6. Risk of breast cancer among women with benign ovarian tumors: a Danish nationwide cohort study vol.178, pp.1, 2013, https://doi.org/10.1007/s10549-019-05369-8