Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Association Study between DRD2 Genetic Polymorphisms and Schizophrenia in a Korean Population

한국인 조현병 환자와 도파민 D2 수용체 유전자 다형성과의 관련연구

  • Kim, Tae-Sung (Department of Psychiatry, Chungnam National University Hospital) ;
  • Cha, Seung-Min (Department of Psychiatry, Chungnam National University Hospital) ;
  • Wang, Seong-Keun (Department of Psychiatry, School of Medicine, Chungnam National University) ;
  • Kim, Jeong-Lan (Department of Psychiatry, School of Medicine, Chungnam National University) ;
  • Lee, Young-Ho (Department of Anatomy, School of Medicine, Chungnam National University) ;
  • Choi, Hye-In (Department of Anatomy, School of Medicine, Chungnam National University) ;
  • Chee, Ik-Seung (Department of Psychiatry, School of Medicine, Chungnam National University)
  • 김태성 (충남대학병원 정신건강의학과) ;
  • 차승민 (충남대학병원 정신건강의학과) ;
  • 왕성근 (충남대학교 의학전문대학원 정신건강의학교실) ;
  • 김정란 (충남대학교 의학전문대학원 정신건강의학교실) ;
  • 이영호 (충남대학교 의학전문대학원 해부학교실) ;
  • 최혜인 (충남대학교 의학전문대학원 해부학교실) ;
  • 지익성 (충남대학교 의학전문대학원 정신건강의학교실)
  • Received : 2011.08.19
  • Accepted : 2011.09.20
  • Published : 2012.02.29
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Abstract

Objectives : This study was designed to investigate the association between the dopamine D2 receptor (DRD2) genetic polymorphism [TaqIB (rs17294542) and TaqID (rs1800498)] and patients with schizophrenia. Methods : TaqIB (rs17294542) and TaqID (rs1800498) polymorphism of the DRD2 gene were typed in 100 patients with schizophrenia and 109 normal controls. Results : There were no statistical differences in genotype and allele distribution of TaqIB (rs17294542) and TaqID (rs1800498) genetic polymorphism between patients with schizophrenia and normal controls. Conclusions : These results suggest that the TaqIB (rs17294542) and TaqID (rs1800498) polymorphisms of the DRD2 gene may not be associated with schizophrenia in the Korean population.

Keywords

References

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