The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
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Effect of Cassia tora Extracts on D-Galactosamine-induced Liver Injury in Rats

결명자 추출물이 D-Galactosamine 유발 간 손상에 미치는 영향

  • Hong, Kyung-Hee (Dept. of Food and Nutrition, Baewha Women's University) ;
  • Um, Min-Young (Division of Metabolism and Functionality Research, Korea Food Research Institute) ;
  • Ahn, Ji-Yun (Division of Metabolism and Functionality Research, Korea Food Research Institute) ;
  • Ha, Tae-Youl (Division of Metabolism and Functionality Research, Korea Food Research Institute)
  • 홍경희 (배화여자대학교 식품영양과) ;
  • 엄민영 (한국식품연구원 대사기능연구본부) ;
  • 안지윤 (한국식품연구원 대사기능연구본부) ;
  • 하태열 (한국식품연구원 대사기능연구본부)
  • Received : 2012.07.27
  • Accepted : 2012.08.20
  • Published : 2012.09.30
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Abstract

This study was performed to evaluate the biological activity and protective effect of Cassia tora ethanol extracts against D-galactosamine induced hepatotoxicity in rats. Male Sprague-Dawley rats were grouped into normal group, D-galactosamine treated group(control), D-galactosamine plus 0.25% Cassia tora extracts treated group and D-galactosamine plus 0.5% Cassia tora extracts treated group. Normal and control group were fed control diet and Cassia tora extracts treated groups were fed experimental diets containing 0.25% or 0.5% Cassia tora ethanol extracts for 5 weeks. Body weight gain and liver weight of rats were not significantly different between groups. Cholesterol and triglyceride concentrations in serum and liver were significantly lower in rats treated only with D-galactosamine compared to normal group, and improved in Cassia tora extracts supplemented rats. D-galactosamine treatment significantly increased serum aspartate transaminase, alanine transaminase, gamma glutamyl transferase and alkaline phosphatase, however, the activities of aspartate transaminase and alanine transaminase were significantly decreased in Cassia tora extracts supplemented rats when compared with D-galactosamine treated control group. Cassia tora extracts significantly suppressed the D-galactosamine-induced elevation of liver thiobarbituric acid reactive substances(TBARS) contents. Superoxide dismutase activity was decreased by D-galactosamine treatment, however by the supplementation of Cassia tora ethanol extracts, significantly increased in dose-dependent manner. Glutathione peroxidase activity in rats fed diets containing Cassia tora extracts was decreased compared to control. Based on these results, we concluded that Cassia tora ethanol extracts may prevents the D-galactosamine-induced hepatotoxicity probably via an antioxidant mechanism.

Keywords

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