Nutrition Research and Practice

The Korean Nutrition Society (한국영양학회)
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Effect of resveratrol on the metastasis of 4T1 mouse breast cancer cells in vitro and in vivo

  • Lee, Hyun-Sook (Department of Food Science and Nutrition, Dongseo University) ;
  • Ha, Ae-Wha (Department of Food Science and Nutrition, Dankook University) ;
  • Kim, Woo-Kyoung (Department of Food Science and Nutrition, Dankook University)
  • Received : 2011.12.07
  • Accepted : 2012.04.30
  • Published : 2012.08.31
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Abstract

We investigated the effects of resveratrol on metastasis in in vitro and in vivo systems. 4T1 cells were cultured in the presence of various concentrations (0-30 ${\mu}mol/L$) of resveratrol. For experimental metastasis, BALB/c mice were injected intravenously with 4T1 cells in the tail vein, and were orally administered various concentrations (0, 100, or 200 mg/kg Body weight) of resveratrol for 21 days. After resveratrol treatment, cell adhesion, wound migration, invasion, and MMP-9 activity were significantly decreased in a dose-dependent manner in 4T1 cells (P < 0.05). The numbers of pulmonary nodules were significantly decreased in mice fed the resveratrol (P < 0.05). The plasma MMP-9 activity was decreased in response to treatment with resveratrol in mice (P < 0.05). We conclude that resveratrol inhibits cancer metastasis both in vitro and in vivo, and this inhibition is likely due to the decrease in MMP-9 activity caused by resveratrol.

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References

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